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卡纽替尼二盐酸盐
CI-1033
产品别名
289499-45-2
卡纽替尼二盐酸盐
CI-1033
N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-2-propenamide dihydrochloride
PD183805
N-[4-(3-Chloro-4-fluorophenylamino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]acrylamide dihydrochloride
Canertinib dihydrochloride
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C24H25ClFN5O3· 2HCl |
| Molecular weight | 558.86 |
| MDL number | MFCD09954112 |
| PubChem Substance ID【PubChem化学物质编号】 | 329775143 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | CI-1033 is a potent, irreversible ATP binding site–directed pan-ErbB tyrosine kinase inhibitor with IC50 in the low nanomolar range for EGFR, HER2, and ErbB-4. |
| Features and Benefits【特点和优势】 | This compound is featured on the EGFR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | solid |
| solubility【溶解性】 | DMSO: >10 mg/mL H2O: >10 mg/mL |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | Cl.Cl.Fc1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)c(NC(=O)C=C)cc23)cc1Cl |
| InChI | 1S/C24H25ClFN5O3.2ClH/c1-2-23(32)30-21-13-17-20(14-22(21)34-9-3-6-31-7-10-33-11-8-31)27-15-28-24(17)29-16-4-5-19(26)18(25)12-16;;/h2,4-5,12-15H,1,3,6-11H2,(H,30,32)(H,27,28,29);2*1H |
| InChI key | JZZFDCXSFTVOJY-UHFFFAOYSA-N |
| Gene Information | human ... EGFR(1956), ERBB2(2064), ERBB4(2066) |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H315 - H319 - H335 |
| Precautionary Statements | P261 - P305 + P351 + P338 |
| Hazard Classifications【危险分类】 | Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3 |
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
