CI 976

C₂₃H₃₉NO₄

393.56

MFCD00869662

329775044

NA.77

CI 976 has been used as an acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor:

• to analyze its anti-hepatitis C virus (HCV) activity in Huh7.5.1 cells
• to treat Neuro-2a cells to test its effect on plasma membrane integrated density of α4-SEPβ2 or α6-SEPβ2β3 nicotinic acetylcholine receptors (nAChRs)
• to study its effects on the anti-angiogenic activity of pyripyropenes in human umbilical vein endothelial cells

CI-976, a new trimethoxy fatty acid anilide, is a potent and specific inhibitor of liver and intestinal acyl coenzyme A; cholesterol acyltransferase (ACAT) in vitro. CI-976 decreased non-high density lipoprotein (HDL)-cholesterol and increased HDL-cholesterol in rats with pre-established dyslipidemia. High performance gel chromatographic separation of plasma lipoproteins also revealed that CI-976, but not CL 277,082, lowered low density lipoprotein (LDL)-cholesterol and elevated HDL-cholesterol.

100

>98% (HPLC)

solid

DMSO: >10 mg/mL
H₂O: insoluble <2 mg/mL

2-8℃

CCCCCCCCCCC(C)(C)C(=O)Nc1c(OC)cc(OC)cc1OC

1S/C23H39NO4/c1-7-8-9-10-11-12-13-14-15-23(2,3)22(25)24-21-19(27-5)16-18(26-4)17-20(21)28-6/h16-17H,7-15H2,1-6H3,(H,24,25)

WAFNZAURAWBNDZ-UHFFFAOYSA-N

5 mg in glass bottle

H413

Aquatic Chronic 4

13 - Non Combustible Solids

WGK 3

Eyeshields, Gloves, type N95 (US)