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Chk2 抑制剂 II 水合物
Chk2 Inhibitor II hydrate
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| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 3424956 | 5 MG | 2840 | |||
| 3424956 | 25 MG | 7940 |
产品别名
516480-79-8
Chk2 抑制剂 II 水合物
Chk2 Inhibitor II hydrate
2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide hydrate
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C20H14ClN3O2 · xH2O |
| Molecular weight | 363.80 (anhydrous basis) |
| MDL number | MFCD08276917 |
| PubChem Substance ID【PubChem化学物质编号】 | 24724438 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | Chk2 Inhibitor II is a checkpoint kinase 2 inhibitor, which controls the p53 response to DNA breaks induced by radiation, leading to apoptosis. Protection of T-cells from apoptosis implies use as an adjuvant for radiation therapy in cancer. IC50 = 15 nM; Ki = 37 nM. Chk2 Inhibitor II shows 1000-fold greater selectivity for the Chk2 serine/threonine kinase than for the Cdk1/B and CK1 kinases (for which IC50 = 12 μM and 17 μM, respectively). Chk2 Inhibitor II weakly inhibits a panel of 31 other kinases (<25% inhibition at a concentration of 10 μM and prevents apoptosis of human CD4+ and CD8+ T-cells subjected to ionizing radiation (EC50 = 3 μM and 7.6 μM, respectively). |
| Features and Benefits【特点和优势】 | This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | solid |
| color【颜色】 | off-white to tan |
| solubility【溶解性】 | DMSO: ≥2 mg/mL (warmed) |
| originator【创始人】 | Johnson & Johnson |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O=C(C1=CC=C2C(N=C(C3=CC=C(OC4=CC=C(Cl)C=C4)C=C3)N2)=C1)N |
| InChI | 1S/C20H14ClN3O2/c21-14-4-8-16(9-5-14)26-15-6-1-12(2-7-15)20-23-17-10-3-13(19(22)25)11-18(17)24-20/h1-11H,(H2,22,25)(H,23,24) |
| InChI key | UXGJAOIJSROTTN-UHFFFAOYSA-N |
| Gene Information | human ... CHEK2(11200) |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
