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CBIQ
产品编号: | 3423728 |
规格: | ≥98% (HPLC), solid |
CAS NO: | 32081-28-0 |
包装规格: | 5 MG,25 MG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
32081-28-0
CBIQ
4-Chlorobenzo[f]isoquinoline
结构式
基本信息
Empirical Formula【经验(实验)分子式】 | C13H8NCl |
Molecular weight | 213.66 |
MDL number | MFCD02179769 |
PubChem Substance ID【PubChem化学物质编号】 | 24724450 |
NACRES | NA.77 |
Biochem/physiol Actions【生化/生理作用】 | CBIQ is an activator of the cystic fibrosis transmembrane conductance regulator (CFTR) and the intermediate-conductance calcium-sensitive K+ channel (KCNN4). CBIQ is a novel tool for a new ion channel; first activator of ΔF508 CFTR, the mutant form of CFTR chloride channel present in 75% of cystic fibrosis patients. Other benzoquinolines act at the normal CFTR but not at ΔF508 CFTR. CBIQ also activates KCNN4, which hyperpolarizes airway epithelial cells to promote anion flux, a further benefit in cystic fibrosis. |
Features and Benefits【特点和优势】 | This compound is featured on the Chloride Channels and Potassium Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. |
产品性质
Quality Level【质量水平】 | 100 |
Assay【测定】 | ≥98% (HPLC) |
form【形式】 | solid |
color【颜色】 | off-white |
solubility【溶解性】 | DMSO: 15 mg/mL |
SMILES string | Clc1nccc2c1ccc3ccccc23 |
InChI | 1S/C13H8ClN/c14-13-12-6-5-9-3-1-2-4-10(9)11(12)7-8-15-13/h1-8H |
InChI key | SHQLTRRYZVBEMR-UHFFFAOYSA-N |
packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
Pictograms【象形图】 | GHS05,GHS06 |
Signal word【警示用语:】 | Danger |
Hazard Statements | H301 - H315 - H318 - H335 |
Precautionary Statements | P280 - P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338 + P310 |
Hazard Classifications【危险分类】 | Acute Tox. 3 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3 |
Target Organs【靶器官】 | Respiratory system |
Storage Class Code【储存分类代码】 | 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects |
WGK | WGK 3 |
Personal Protective Equipment【个人防护装备】 | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |