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CBIQ

产品编号:3423728
规格:≥98% (HPLC), solid
CAS NO:32081-28-0
包装规格:5 MG,25 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
34237285 MG2650
342372825 MG10060
产品别名

32081-28-0

CBIQ

4-Chlorobenzo[f]isoquinoline

结构式
基本信息
Empirical Formula【经验(实验)分子式】
C13H8NCl
Molecular weight
213.66
MDL number
MFCD02179769
PubChem Substance ID【PubChem化学物质编号】
24724450
NACRES
NA.77
Biochem/physiol Actions【生化/生理作用】
CBIQ is an activator of the cystic fibrosis transmembrane conductance regulator (CFTR) and the intermediate-conductance calcium-sensitive K+ channel (KCNN4). CBIQ is a novel tool for a new ion channel; first activator of ΔF508 CFTR, the mutant form of CFTR chloride channel present in 75% of cystic fibrosis patients. Other benzoquinolines act at the normal CFTR but not at ΔF508 CFTR. CBIQ also activates KCNN4, which hyperpolarizes airway epithelial cells to promote anion flux, a further benefit in cystic fibrosis.
Features and Benefits【特点和优势】
This compound is featured on the Chloride Channels and Potassium Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥98% (HPLC)
form【形式】
solid
color【颜色】
off-white
solubility【溶解性】
DMSO: 15 mg/mL
SMILES string
Clc1nccc2c1ccc3ccccc23
InChI
1S/C13H8ClN/c14-13-12-6-5-9-3-1-2-4-10(9)11(12)7-8-15-13/h1-8H
InChI key
SHQLTRRYZVBEMR-UHFFFAOYSA-N
packaging【包装】
5, 25 mg in glass bottle
安全信息
Pictograms【象形图】
GHS05,GHS06
Signal word【警示用语:】
Danger
Hazard Statements
H301 - H315 - H318 - H335
Precautionary Statements
P280 - P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338 + P310
Hazard Classifications【危险分类】
Acute Tox. 3 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
Target Organs【靶器官】
Respiratory system
Storage Class Code【储存分类代码】
6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK
WGK 3
Personal Protective Equipment【个人防护装备】
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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