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BVT.948
产品别名
39674-97-0
BVT.948
4-Hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C14H11NO3 |
| Molecular weight | 241.24 |
| MDL number | MFCD00616487 |
| PubChem Substance ID【PubChem化学物质编号】 | 24724422 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | BVT.948 is a non-competitive inhibitor of protein tyrosine phosphatase (PTP). Enhances insulin signaling in cells and inhibits several cytochrome P450 isoforms in vitro. |
| Features and Benefits【特点和优势】 | BVT.948 is a non-competitive inhibitor of protein tyrosine phosphatase (PTP). Enhances insulin signaling in cells and inhibits several cytochrome P450 isoforms in vitro. Works through a different mechanism then the other PTP inhibitors. BVT.948 was able to enhance insulin signaling in cells, although it did not increase tyrosine phosphorylation globally. Furthermore, the compound was active in vivo, enhancing insulin tolerance tests in ob/ob mice, therefore apparently enhancing insulin sensitivity. BVT.948 was able to inhibit several other PTPs tested and also was efficient at inhibiting several cytochrome P450 isoforms in vitro. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | solid |
| storage condition【储存条件】 | desiccated protect from light under inert gas |
| color【颜色】 | red |
| solubility【溶解性】 | DMSO: 18 mg/mL H2O: insoluble |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | CC1(C)C(=O)N=C2c3ccccc3C(=O)C(O)=C12 |
| InChI | 1S/C14H11NO3/c1-14(2)9-10(15-13(14)18)7-5-3-4-6-8(7)11(16)12(9)17/h3-6,17H,1-2H3 |
| InChI key | BAQXWJQSUXZVIP-UHFFFAOYSA-N |
| packaging【包装】 | 1 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H317 |
| Precautionary Statements | P280 |
| Hazard Classifications【危险分类】 | Skin Sens. 1 |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
