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BEPP monohydrochloride
产品别名
455311-98-5
BEPP monohydrochloride
1H-Benzimidazole-1-ethanol, 2,3-dihydro-2-imino-alpha-(phenoxymethyl)-3-(phenylmethyl)- monohydrochloride
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C23H23N3O2 HCl |
| Molecular weight | 409.91 |
| MDL number | MFCD00964481 |
| PubChem Substance ID【PubChem化学物质编号】 | 329773209 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | BEPP is a double-strand RNA-dependent protein kinase (PKR) activator. The double-strand RNA (dsRNA)-dependent protein kinase is a ubiquitously expressed serine threonine kinase, inducible by interferon γ. PRK is involved in several curtail cellular regulations including phosphorylation of eIF2α (which leads to inhibition of protein synthesis and eliciting antivirus and antitumor activities), modulating activities of eIF2α, NF-κB, ATF-3, and p53. BEPP also inhibits the growth of a human lung cancer cell line overexpressing PKR. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| storage condition【储存条件】 | desiccated |
| color【颜色】 | white to off-white |
| solubility【溶解性】 | DMSO: >10 mg/mL |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | Cl.OC(COc1ccccc1)CN2C(=N)N(Cc3ccccc3)c4ccccc24 |
| InChI | 1S/C23H23N3O2.ClH/c24-23-25(15-18-9-3-1-4-10-18)21-13-7-8-14-22(21)26(23)16-19(27)17-28-20-11-5-2-6-12-20;/h1-14,19,24,27H,15-17H2;1H |
| InChI key | KDMXJFUGIDGZQL-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 1 |
