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ANTI-ZO1(C-TERMINAL) antibody produced in rabbit
| 产品编号： | 3408658 |
| 规格： | purified immunoglobulin, buffered aqueous solution |
| 包装规格： | 400 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
ANTI-ZO1(C-TERMINAL) antibody produced in rabbit
Zona occludens protein 1
Tight junction protein ZO-1
TJP1
Tight junction protein 1
ZO1
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | Tight junction protein 1 (TJP1) or zona occludens protein 1 (ZO1) is an adaptor protein. It acts as a scaffold protein between the tight junction and actin cytoskeleton. ZO1 has a molecular weight of 220kDa and is part of the membrane-associated guanylate kinase homolog family. The protein possesses three PDZ domains at its amino terminal, an SH3 domain and a region which bears homology to guanylate kinase. The ZO1 gene is localized on human chromosome 15q13.1. |
| Application【应用】 | ANTI-ZO1(C-TERMINAL) antibody produced in rabbit has been used in immunofluorescence. |
| Biochem/physiol Actions【生化/生理作用】 | Tight junction protein 1 (TJP1) or zona occludens protein 1 (ZO1) has a role in the formation of epithelial lumens. It interacts with occludin and modulates tight junction barrier regulation. ZO1 is also involved in the formation of the odontoblast layer and in actomyosin cytoskeleton regulation. Low expression of ZO1 has been linked to increased cell invasiveness in breast cancer, colorectal cancer and digestive tract cancers. |
| Physical form【外形】 | Supplied in PBS with 0.09% (W/V) sodium azide |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | 195459 Da |
| species reactivity | human |
| technique(s) | flow cytometry: 1:10-1:50 immunohistochemistry: 1:50-1:100 western blot: 1:1000 |
| NCBI accession no.【NCBI登记号】 | NP_003248.3 |
| UniProt accession no.【UniProt登记号】 | Q07157 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... TJP1(7082) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
