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Anti-SIGLEC7 (D-siglec) (C-term H422) antibody produced in rabbit

产品编号:3395176
规格:IgG fraction of antiserum, buffered aqueous solution
包装规格:100 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
3395176100 μG5040
产品别名

Anti-SIGLEC7 (D-siglec) (C-term H422) antibody produced in rabbit

Anti-p75

Anti-Adhesion inhibitory recptor molecule-1

Anti-AIRM-1

Anti-Siglec-7

Anti-QA79 membrane protein

基本信息
NACRES
NA.41
General description【一般描述】
SIGLECs are cell surface proteins of the Ig superfamily. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. A large subgroup of SIGLECs share high homology with SIGLEC3 (CD33) and are localized to 19q13.4. The cDNA for the SLG gene encodes 2 variants, SLG-long (SLGL) and SLG-short (SLGS). The 595-amino acid SLGL protein contains a signal peptide and 2 V-set N-terminal Ig-like domains. The 477-amino acid SLGS protein has a weak signal sequence and, like most SIGLEC3-like SIGLECs, has only 1 V-set N-terminal Ig-like domain. Both variants contain 2 C2-set N-terminal Ig-like domains, a transmembrane domain, and a cytoplasmic tail with a putative ITIM and a putative SLAM-like tyrosine-based motif. The conserved arginine residue thought to be essential for sialic acid binding in other SIGLECs is replaced by a glutamine in SLGS and by a cysteine in SLGL. RT-PCR analysis detected high expression of both variants in spleen and small intestine, and SLGS was highly expressed in adrenal gland and SLGL was highly expressed in bone marrow. This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human D-siglec.
Immunogen【免疫原】
SIGLEC7 (Q9NZQ1, 412-448)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human D-siglec.
Physical form【外形】
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
100
conjugate【偶联物】
unconjugated
antibody form【抗体形式】
IgG fraction of antiserum
antibody product type
primary antibodies
clone【克隆】
polyclonal
form【形式】
buffered aqueous solution
species reactivity
human
technique(s)
immunohistochemistry: 1:50-1:100
indirect ELISA: 1:1000
western blot: 1:100-1:500
NCBI accession no.【NCBI登记号】
NP_057627
UniProt accession no.【UniProt登记号】
Q9Y286
shipped in【运输】
dry ice
storage temp.【储存温度】
−20℃
Gene Information
human ... SIGLEC7(27036)
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
nwg
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