Anti-SHC1 (Ab-349) antibody produced in rabbit

MFCD01634176

NA.41

Peptide sequence around aa. 347-351 (H-Q-Y-Y-N), according to the protein SHC1.

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Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

rabbit

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous solution

~46 kDa
~52 kDa

human, mouse, rat

1 mg/mL

indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000

IgG

(H-Q-Y-Y-N)

NP_001123512.1

P29353

wet ice

−20℃

human ... SHC1(6464)

Signaling adapter that couples activated growth factor receptors to signaling pathway. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span.

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12 - Non Combustible Liquids

WGK 1