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Anti-SH3GL1 antibody produced in chicken

产品编号:3394898
规格:affinity isolated antibody, buffered aqueous solution
包装规格:50 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
339489850 μG4690
基本信息
NACRES
NA.41
General description【一般描述】
SH3GL1 (SH3-domain GRB2-like 1), also called EA2 (endophilin A2), was initially recognized as a fusion partner of MLL (mixed-lineage leukaemia) translocation in childhood leukaemia. It is the first member of the EEN/EA SH3 domain (Src homology 3 domain)-containing family of proteins. It is found in the cells of haemopoietic, fibroblast and epithelial lineage, where it resides primarily in the nucleus. In neurons and osteoclasts, its primary localization is in cytoplasm, thus suggesting its shuttles between nucleus and cytoplasm.
Immunogen【免疫原】
Immunogen Sequence: GI # 4506929, sequence 1-360
Recombinant SH3-domain GRB2-like 1
Application【应用】
Anti-SH3GL1 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions【生化/生理作用】
SH3GL1 (SH3-domain GRB2-like 1) or endophilin-A2 is involved in the formation of endocytic vesicles. The protein is a 50- to 60-amino-acid module carried by intracellular proteins involved in the transduction of signals for cell polarization, motility, enzymatic activation, and transcriptional regulation. SH3GL1 is expressed ubiquitously. It is one of the main accessory proteins involved in clathrin-mediated endocytosis and it interacts with other endocytic proteins, such as dynamin, by its SH3 domain. SH3GL1 may be one of the pathogenic genes for idiopathic scoliosis (IS) and may be associated with adolescent idiopathic scoliosis (AIS). It may have some role in the cell cycle. SH3GL1 may be involved in the oncogenic process of gliomas.
Physical form【外形】
Solution in phosphate buffered saline containing 0.02% sodium azide.
产品性质
biological source【生物来源】
chicken
Quality Level【质量水平】
200
conjugate【偶联物】
unconjugated
antibody form【抗体形式】
affinity isolated antibody
antibody product type
primary antibodies
clone【克隆】
polyclonal
form【形式】
buffered aqueous solution
species reactivity
rat, human, mouse
technique(s)
western blot: suitable
NCBI accession no.【NCBI登记号】
NP_003016.1
UniProt accession no.【UniProt登记号】
Q6FGM0
shipped in【运输】
wet ice
storage temp.【储存温度】
−20℃
Gene Information
human ... SH3GL1(6455)
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 1
Personal Protective Equipment【个人防护装备】
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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