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Anti-SH3GL1 antibody produced in chicken
产品编号: | 3394898 |
规格: | affinity isolated antibody, buffered aqueous solution |
包装规格: | 50 μG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
基本信息
NACRES | NA.41 |
General description【一般描述】 | SH3GL1 (SH3-domain GRB2-like 1), also called EA2 (endophilin A2), was initially recognized as a fusion partner of MLL (mixed-lineage leukaemia) translocation in childhood leukaemia. It is the first member of the EEN/EA SH3 domain (Src homology 3 domain)-containing family of proteins. It is found in the cells of haemopoietic, fibroblast and epithelial lineage, where it resides primarily in the nucleus. In neurons and osteoclasts, its primary localization is in cytoplasm, thus suggesting its shuttles between nucleus and cytoplasm. |
Immunogen【免疫原】 | Immunogen Sequence: GI # 4506929, sequence 1-360 Recombinant SH3-domain GRB2-like 1 |
Application【应用】 | Anti-SH3GL1 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200. |
Biochem/physiol Actions【生化/生理作用】 | SH3GL1 (SH3-domain GRB2-like 1) or endophilin-A2 is involved in the formation of endocytic vesicles. The protein is a 50- to 60-amino-acid module carried by intracellular proteins involved in the transduction of signals for cell polarization, motility, enzymatic activation, and transcriptional regulation. SH3GL1 is expressed ubiquitously. It is one of the main accessory proteins involved in clathrin-mediated endocytosis and it interacts with other endocytic proteins, such as dynamin, by its SH3 domain. SH3GL1 may be one of the pathogenic genes for idiopathic scoliosis (IS) and may be associated with adolescent idiopathic scoliosis (AIS). It may have some role in the cell cycle. SH3GL1 may be involved in the oncogenic process of gliomas. |
Physical form【外形】 | Solution in phosphate buffered saline containing 0.02% sodium azide. |
产品性质
biological source【生物来源】 | chicken |
Quality Level【质量水平】 | 200 |
conjugate【偶联物】 | unconjugated |
antibody form【抗体形式】 | affinity isolated antibody |
antibody product type | primary antibodies |
clone【克隆】 | polyclonal |
form【形式】 | buffered aqueous solution |
species reactivity | rat, human, mouse |
technique(s) | western blot: suitable |
NCBI accession no.【NCBI登记号】 | NP_003016.1 |
UniProt accession no.【UniProt登记号】 | Q6FGM0 |
shipped in【运输】 | wet ice |
storage temp.【储存温度】 | −20℃ |
Gene Information | human ... SH3GL1(6455) |
安全信息
Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
WGK | WGK 1 |
Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |