Anti-Ring1A antibody produced in rabbit

NA.41

The antibody detects endogenous level of total Ring1A protein.

Peptide sequence around aa. 35-39 ( I-A-V-S-P), according to the protein NP_002922.2

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Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

rabbit

100

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous solution

~58 kDa

human, rat, mouse

1 mg/mL

western blot: 1:500-1:1000

IgG

(I-A-V-S-P)

NM_002931.3

wet ice

−20℃

human ... Ring1A(6015)

Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of ′Lys-119′ of histone H2A, thereby playing a central role in histone code and gene regulation. H2A ′Lys-119′ ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex act via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity.

10 - Combustible liquids

WGK 1