您的位置：首页 > 产品中心 > Anti-PSMC3IP antibody produced in rabbit
Anti-PSMC3IP antibody produced in rabbit
产品别名
Anti-PSMC3IP antibody produced in rabbit
Anti-PSMC3 interacting protein
Anti-TBPIP
Anti-HOP2
Anti-GT198
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | PSMC3IP (HOP2) forms a part of the PSMC3IP/MND1 complex that associates with PSMC3/TBP1 and regulates strand exchange during meiotic recombination. A mutation in PSMC3IP has been associated with XX ovarian dysgenesis. Rabbit anti- PSMC3IP antibody recognizes canine, human, bovine, rat, and mouse PSMC3IP. |
| Immunogen【免疫原】 | Synthetic peptide directed towards the middle region of human PSMC3IP |
| Application【应用】 | Rabbit anti- PSMC3IP antibody is suitable for western blot applications at a concentration of 1.25μg/ml. |
| Biochem/physiol Actions【生化/生理作用】 | PSMC3IP plays an important role in meiotic recombination. It stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. It may inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3. |
| Sequence【序列】 | Synthetic peptide located within the following region: RLKNIKAATNHVTPEEKEQVYRERQKYCKEWRKRKRMATELSDAILEGYP |
| Physical form【外形】 | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | 25 kDa |
| species reactivity | horse, human, dog |
| concentration【浓度】 | 0.5 mg - 1 mg/mL |
| technique(s) | western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_037422 |
| UniProt accession no.【UniProt登记号】 | Q9P2W1 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... PSMC3IP(29893) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
