Anti-PPYR1 antibody produced in rabbit

NA.41

Maxi-K channels, also known as BK channels, consist of a pore-forming alpha subunit and a regulatory beta subunit, which confers the channel with a higher calcium sensitivity. Homologs of the Drosophila melanogaster calcium-activated potassium channel gene, slowpoke, the mouse and human genes generate multiple transcripts by alternative splicing. The splice variants differ significantly in their Ca2+ sensitivity, suggesting a broad functional role for these channels in the regulation of neuronal excitability. The alpha-subunit shows a tissue distribution different to that of the beta-subunit, and in many tissues there may be no association of alpha-subunits with beta-subunits. The beta-subunits can play a functional role in the regulation of neuronal excitability by tuning the Ca2+ and/or the voltage dependence of alpha-subunits (Tseng-Crank et al., 1996). Maxi-K channels may have potential utility of gene therapy for urinary incontinence and erectile dysfunction.

Synthetic 17 amino acid peptide from C-terminus of human PPYR1. Percent identity with other species by BLAST analysis: Human, Gibbon (100%); Gorilla, Panda (94%); Monkey, Bovine, Horse, Pig (88%); Bat, Rabbit (82%).

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Supplied at 1 mg/ml
Solution in phosphate-buffered saline containing less than 0.1% sodium azide.

rabbit

100

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous solution

human

immunohistochemistry: 4-6 μg/mL

dry ice

−20℃

human ... PPYR1(5540)

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