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Anti-PINK1 (N-terminal) antibody produced in rabbit
| 产品编号： | 3386325 |
| 规格： | ~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution |
| 包装规格： | 200 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-PINK1 (N-terminal) antibody produced in rabbit
Anti-PARK6
Anti-PTEN-induced putative kinase 1
Anti-BRPK
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | PINK1 (PTEN induced putative kinase 1, also known as PARK6, BRPK), has been identified as linked to the autosomal recessive form of familial Parkinson′s disease (PD). PINK1 is a Ser/Thr kinase that has been localized to the mitochondria. PINK1 contains an N-terminal mitochondrial targeting motif and a highly conserved kinase domain homologous to Ser/Thr kinases of the Ca2+/calmodulin family. |
| Application【应用】 | Anti-PINK1 (N-terminal) antibody produced in rabbit has been used in immunoblotting. |
| Biochem/physiol Actions【生化/生理作用】 | PINK1 (PTEN induced putative kinase 1) has been found to protect neurons from stress-induced mitochondrial dysfunction and apoptosis. It may protect cells from stress-induced mitochondrial dysfunction. Genetic studies in Drosophila indicate that PINK1 acts upstream of Parkin in a common pathway that influences mitochondrial morphology. PINK1 elicits protection in mouse primary neurons from the dopaminergic neurotoxin 1-methyl-4-phenylpyridine (MPP+)/1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) both in vitro and in vivo. In response to enhanced proteasomal stress in vitro, PINK1 has been shown to be cleaved and localized to the mitochondria, and this correlates with increased expression of the processed PINK1 protein in Parkinson′s disease (PD) brain. |
| Physical form【外形】 | 0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。 |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 200 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen ~60 kDa |
| species reactivity | human |
| packaging【包装】 | antibody small pack of 25 μL |
| enhanced validation【增强验证】 | recombinant expression Learn more about Antibody Enhanced Validation |
| concentration【浓度】 | ~1.5 mg/mL |
| technique(s) | western blot: 4-8 μg/mL using HEK-293T cell lysate expressing human PINK1 |
| UniProt accession no.【UniProt登记号】 | Q9BXM7 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... PINK1(65018) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
