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Anti-phospho-WAVE-1 (pSer397) antibody produced in rabbit
| 产品编号： | 3385969 |
| 规格： | ~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution |
| 包装规格： | 200 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-phospho-WAVE-1 (pSer397) antibody produced in rabbit
Anti-WASF1
Anti-SCAR1
Anti-WASP Family, Member 1
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | WAS protein family member 1 (WAVE-1) is encoded by the gene mapped to human chromosome 6q21. The encoded protein contains small WH2 acidic domain, a cofilin-like domain, proline-rich domain at C-terminal end and EVH1 domain at N-terminal end. WAVE-1 is active mainly in the brain and lungs, but its mRNA is also found in the placenta, liver and pancreas. |
| Biochem/physiol Actions【生化/生理作用】 | WAS protein family member 1 (WAVE-1) functions as a key pro-autophagic protein. The protein has an ability to increase cell survival rate. In addition, it also controls chemoresistance in leukemia cells via Beclin1/ B-cell lymphoma 2 (Bcl)-2 and Beclin1/ phosphatidylinositol 3-kinases (PI3K)-III complex-dependent pathways. The encoded protein enhances ovarian cancer cell proliferation, migration and invasion via activating PI3K/AKT (protein kinase B) and mitogen activated protein kinase p38 (p38MAPK) signaling pathways. |
| Physical form【外形】 | Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 200 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen ~75 kDa |
| species reactivity | rat (predicted), human (predicted), mouse |
| concentration【浓度】 | ~1.5 mg/mL |
| technique(s) | western blot: 1-2 μg/mL using mouse brain extract (S1 fraction) |
| UniProt accession no.【UniProt登记号】 | Q92558 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... WASF1(8936) mouse ... Wasf1(83767) rat ... Wasf1(294568) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
