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Anti-phospho-TP53 (pSer46) antibody produced in rabbit
产品别名
Anti-phospho-TP53 (pSer46) antibody produced in rabbit
Anti-LFS1 antibody produced in rabbit
Anti-TRP53 antibody produced in rabbit
Anti-p53 antibody produced in rabbit
Anti-tumor protein p53 antibody produced in rabbit
Anti-FLJ92943 antibody produced in rabbit
基本信息
| MDL number | MFCD00164709 |
| NACRES | NA.41 |
| Immunogen【免疫原】 | Peptide sequence around phosphorylation site of serine 46 (M-L-S(p)-P-D), according to the protein TP53. |
| Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| Physical form【外形】 | Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | ~53 kDa |
| species reactivity | human |
| concentration【浓度】 | 1 mg/mL |
| technique(s) | indirect immunofluorescence: 1:100-1:200 western blot: 1:500-1:1000 |
| isotype【同位素/亚型】 | IgG |
| immunogen sequence【免疫原序列】 | (M-L-SP-P-D) |
| NCBI accession no.【NCBI登记号】 | NP_000537.3 |
| UniProt accession no.【UniProt登记号】 | P04637 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... TP53(7157) |
产品说明
| Target description【目标描述】 | p53 is a nuclear protein which plays an essential role in the regulation of cell cycle specifically in the transition from G0 to G1. It is found in very low levels in normal cells however in a variety of transformed cell lines in high amounts and believed to contribute to transformation and malignancy. The open reading frame of p53 is 393 amino acids long, with the central region (consisting of amino acids from about 100 to 300) containing the DNA-binding domain. This proteolysis-resistant core is flanked by a C-terminal end mediating oligomerization and an N-terminal end containing a strong transcription activation signal. p53 binds as a tetramer to a PBS (p53-Binding Site) and activates the expression of downstream genes that inhibit growth and/or invasion. p53 binds as a tetramer to a p53-binding site (PBS) and to activate the expression of adjacent genes that inhibit growth and/or invasion. Deletion of one or both p53 alleles reduces the expression of tetramers, resulting in decreased expression of the growth inhibitory genes |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
