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Anti-phospho-TDP-43 [pSer409] antibody produced in rabbit
产品别名
Anti-phospho-TDP-43 [pSer409] antibody produced in rabbit
Anti-phospho-ALS10
Anti-phospho-TARDBP
Anti-phospho-TARDP43
Anti-phospho-TAR DNA binding protein 43
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | Transactive response DNA-binding protein 43 (TDP-43) belongs to the family of heterogeneous nuclear ribonucleoproteins (hnRNPs). It has two RNA-recognition motifs and a glycine-rich C-terminal sequence. TDP-43 is expressed in heart, lung, liver and brain, which is localized to the nucleus.. |
| Immunogen【免疫原】 | synthetic peptide containing phosphorylated Ser409 of human TDP-43 conjugated to KLH. The corresponding sequence is identical in mouse TDP-43 |
| Application【应用】 | Anti-phospho-TDP-43 [pSer409] antibody produced in rabbit has been used in:
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| Biochem/physiol Actions【生化/生理作用】 | Transactive response DNA-binding protein 43 (TDP-43) binds to single stranded RNA. It regulates transcription regulation in human immunodeficiency virus (HIV). TDP-43 is the major ubiquinated component of cytoplasmic inclusions in frontotemporal lobe degeneration subtype (FTLD-U) and amyotrophic lateral sclerosis (ALS). Pathological TDP-43 forms abnormal inclusions in neuronal perikarya and neurites. Mutations in TDP-43 is associated with ALS. Abnormal phosphorylation of TDP-43 at Ser409/410 is observed in FTLD-U and ALS, leading to apoptosis. |
| Physical form【外形】 | Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide. |
产品性质
| biological source【生物来源】 | rabbit |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen ~43 kDa |
| species reactivity | human, mouse |
| concentration【浓度】 | ~1.0 mg/mL |
| technique(s) | indirect immunofluorescence: 1-2 μg/mL using HeLa cells western blot: 1-2 μg/mL using HepG2 and A431 cell lysates |
| UniProt accession no.【UniProt登记号】 | Q13148 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... TARDBP(23435) mouse ... Tardbp(230908) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
