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Anti-phospho-PKC α (pTyr657) antibody produced in rabbit
产品别名
Anti-phospho-PKC α (pTyr657) antibody produced in rabbit
PKC III
KPCA
PKC-alpha
PKC-A
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | Protein kinase C α (PRKCA) is encoded by the gene mapped to human chromosome 17q24.2. The encoded protein is a member of the serine/threonine-specific protein kinase family. |
| Specificity【特异性】 | The antibody detects endogenous levels of PKC α only when phosphorylated at tyrosine 658. |
| Immunogen【免疫原】 | Peptide sequence around phosphorylation site of tyrosine 658(F-S-Y(p)-V-N) derived from Human PKC α. |
| Biochem/physiol Actions【生化/生理作用】 | Protein kinase C α (PRKCA) is a serine-threonine kinase. It is associated with tumorigenesis, invasion, apoptosis, differentiation, angiogenesis and metastasis. Downregulation of PKCA inhibits the invasion of urinary bladder, colon, renal cell, breast carcinomas, multiple myeloma, glioma and endometrial cancer cells. In endothelial cells, PRKCA-mediated phosphorylation of TRPC1 (transient receptor potential cation channel subfamily C member 1) regulates store operated Ca2+ entry. |
| Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| Physical form【外形】 | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | 80 kDa |
| species reactivity | human |
| concentration【浓度】 | 1.0 mg/mL |
| technique(s) | western blot: 1:500-1:1000 (Cell Lysate) |
| isotype【同位素/亚型】 | IgG |
| accession no.【登记号】 | NP_002728.1. |
| UniProt accession no.【UniProt登记号】 | P17252 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... PRKCA(5578) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
