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Anti-phospho-p53 (pSer20) antibody produced in rabbit
产品别名
Anti-phospho-p53 (pSer20) antibody produced in rabbit
BCC7
TRP53
LFS1
P53
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | p53, also known as transformation related protein 53 (TRP53), is encoded by the gene mapped to human chromosome 17p13.1. p53 is a tumor suppressor gene expressed in a wide variety of tissues. The gene codes for a tetrameric nuclear DNA-binding phosphoprotein. |
| Specificity【特异性】 | The antibody detects endogenous level of p53 only when phosphorylated at Serine 20. |
| Immunogen【免疫原】 | Peptide sequence around phosphorylation site of Serine 20(T-F-S(p)-D-L) derived from Human p53. |
| Biochem/physiol Actions【生化/生理作用】 | Tumor suppressor p53 has an ability to induce cell cycle arrest. It also plays a key role in DNA repair, senescence and apoptosis. It binds to simian vacuolating virus 40 (SV40) T-antigen and human papilloma virus E6 protein. Mutation in the p53 gene is associated with the development of various types of cancers, such as breast, ovarian, bladder, colon and lung cancer. |
| Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| Physical form【外形】 | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | 53 kDa |
| species reactivity | mouse, human |
| concentration【浓度】 | 1.0 mg/mL |
| technique(s) | western blot: 1:500-1:1000 (Cell Lysate) |
| isotype【同位素/亚型】 | IgG |
| accession no.【登记号】 | NP_000537.3 |
| UniProt accession no.【UniProt登记号】 | P04637 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... TP53(7157) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
