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Anti-phospho-MAPT (pSer262) antibody produced in rabbit
产品别名
Anti-phospho-MAPT (pSer262) antibody produced in rabbit
Anti-MAPTL antibody produced in rabbit
Anti-DDPAC antibody produced in rabbit
Anti-FLJ31424 antibody produced in rabbit
Anti-FTDP-17 antibody produced in rabbit
Anti-microtubule-associated protein tau antibody produced in rabbit
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | MAPT (microtubule associated protein tau) is located on human chromosome 17q21.3 It is highly expressed in neurons but is most prominent in axons |
| Immunogen【免疫原】 | Peptide sequence around phosphorylation site of serine 262 (I-G-S(p)-T-E), according to the protein MAPT. |
| Biochem/physiol Actions【生化/生理作用】 | Removal of MAPT (microtubule associated protein tau) results in developmental delay and learning disability. It participates in the pathology of Alzheimer′s disease (AD). It helps in the assembly and maintenance of microtubule structure |
| Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| Physical form【外形】 | Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | ~48 kDa ~62 kDa ~78 kDa |
| species reactivity | rat, mouse, human |
| concentration【浓度】 | 1 mg/mL |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100 indirect immunofluorescence: 1:100-1:200 western blot: 1:500-1:1000 |
| isotype【同位素/亚型】 | IgG |
| immunogen sequence【免疫原序列】 | (I-G-SP-T-E) |
| NCBI accession no.【NCBI登记号】 | NP_001116538.1 |
| UniProt accession no.【UniProt登记号】 | P10636 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... MAPT(4137) |
产品说明
| Target description【目标描述】 | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
