抗-磷酸化-MAPK8/MAPK9/MAPK10 (pThr¹⁸³/pTyr¹⁸⁵) 兔抗

NA.41

Peptide sequence around phosphorylation site of Thr183/Tyr185 (M-M-T(p)-P-Y(p) - V - V ), according to the protein MAPK8/MAPK9/MAPK10.

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Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

rabbit

100

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous solution

~46 kDa
~54 kDa

mouse, rat, human

1 mg/mL

indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000

IgG

(M-M-TP-P-YP-V-V)

NP_001128516.1
NP_002741.1
NP_002744.1

P45983

wet ice

−20℃

human ... MAPK10(5602), MAPK8(5599), MAPK9(5601)

Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells By similarity. Phosphorylates heat shock factor protein 4 (HSF4). /Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells. JNK2 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to c-Jun, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it. /Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. Required for stress-induced neuronal apoptosis and the pathogenesis of glutamate excitotoxicity

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10 - Combustible liquids

WGK 1