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Anti-phospho-Insulin Receptor/Insulin-Like Growth Factor-1 Receptor (pTyr1158/1162/1163) antibody produced in rabbit
| 产品编号： | 3384926 |
| 规格： | affinity isolated antibody, buffered aqueous solution |
| 包装规格： | 1 VIAL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-phospho-Insulin Receptor/Insulin-Like Growth Factor-1 Receptor (pTyr1158/1162/1163) antibody produced in rabbit
Anti-IR/IGF1R
基本信息
| MDL number | MFCD06201923 |
| NACRES | NA.41 |
| General description【一般描述】 | Insulin-like growth factors -1 and -2 are important regulators of signalling that mediates growth and metabolism in cells. Insulin-like growth factor -1 shares structural homology with proinsulin and is mainly produced by liver. IGF-1 acts via specific receptor, IGF-1R, a heterodimeric tyrosine kinase receptor that signals to various second messenger pathways such as MAPK, Raf/Ras and PI3K cascades. IGF 1R is fully activated by phosphorylation of tyrosine residues at Tyr1158, Tyr1162 and Tyr1163. The effect of IGF-1 is by endocrine, paracrine and autocrine signalling. The effects of IGF-1R signalling are important at many developmental levels from cells to organ to organism, growth, differentiation, anti-apoptosis, proliferation and transformation. Irregular IGF-1 signaling has been implicated in many cancers including melanoma, breast, lung, colon and prostate Anti-phospho-IR/IGF1R (pTyr1158/1162/1163) specifically recognizes human receptor and insulin-like growth factor-1 receptor phosphorylated at tyrosines 1158, 1162 and 1163. It may cross react with mouse and rat IR/IGF1R (100% homology). |
| Immunogen【免疫原】 | synthetic phosphopeptide derived from the region of IR that contains tyrosines 1158, 1162, and 1163. |
| Application【应用】 | Anti-phospho-IR/IGF1R (pTyr1158/1162/1163) antibody may be used for immunoblotting at a working concentration of 0.1-1.0 μg/ml using whole cell lysates from CHO-T cells. |
| Physical form【外形】 | Solution in Dulbecco′s phosphate buffered saline, pH 7.3, containing 50% glycerol, 1 mg/mL BSA (IgG and protease-free) and 0.05% sodium azide. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 200 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| species reactivity | human |
| technique(s) | western blot: 0.1-1.0 mg/mL using stimulated CHO-T cells |
| UniProt accession no.【UniProt登记号】 | P08069 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... IGF1R(3480) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
