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Anti-phospho-DARPP32 (pThr75) antibody produced in rabbit

产品编号:3384488
规格:affinity isolated antibody, buffered aqueous glycerol solution, sufficient for 10 blots
包装规格:1 VIAL
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
33844881 VIAL4730
基本信息
MDL number
MFCD08705496
NACRES
NA.41
General description【一般描述】
DARPP32 is a phosphoprotein with a molecular mass of 32kDa. It is regulated by dopamine (DA) and cAMP and is associated with dopaminoceptive neurons bearing D-1 receptors in the basal ganglia. DARPP32 is a target for the actions of dopamine.
Immunogen【免疫原】
synthetic phosphopeptide corresponding to amino acids residues surrounding the DARPP32 phosphorylated on threonine 75.
Application【应用】
Anti-phospho-DARPP32 (pThr75) antibody produced in rabbit is suitable for dot blot and western blot analysis at a working dilution of 1:1000 using rat caudate lysates.
Biochem/physiol Actions【生化/生理作用】
Dopamine D1 receptor stimulation enhances cAMP formation, resulting in the phosphorylation of DARPP32. Phosphorylation of DARPP32 plays an important role in the regulation of dopaminergic neurotransmission. The activity of this protein has an important role in the actions of alcohol, caffeine and Prozac®.
Physical form【外形】
Solution at 100 μL in 10 mM HEPES, pH 7.5, 150 mM NaCl, 100 μg/mL BSA, and 50% glycerol.
Other Notes【其他说明】
The labeling by the antibody to DARPP32 Thr75 is markedly increased by okadaic acid treatment.
Legal Information【法律信息】
Prozac is a registered trademark of Eli Lilly and Co.
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
200
conjugate【偶联物】
unconjugated
antibody form【抗体形式】
affinity isolated antibody
antibody product type
primary antibodies
clone【克隆】
polyclonal
form【形式】
buffered aqueous glycerol solution
usage【用途】
sufficient for 10 blots
mol wt【分子量】
antigen 32 kDa
species reactivity
mouse, human
technique(s)
dot blot: 1:1,000
western blot: 1:1,000
UniProt accession no.【UniProt登记号】
Q9UD71
shipped in【运输】
wet ice
storage temp.【储存温度】
−20℃
Gene Information
human ... PPP1R1B(84152)
mouse ... Ppp1r1b(19049)
产品说明
Target description【目标描述】
DARPP32 phosphorylated on Thr75 acts as an inhibitor of PKA.
安全信息
Storage Class Code【储存分类代码】
13 - Non Combustible Solids
WGK
WGK 2
Personal Protective Equipment【个人防护装备】
Eyeshields, Gloves, type N95 (US)
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