Anti-PCBP1

NA.41

Poly(rC) binding protein 1 (PCBP1) is a RNA binding protein. The gene is located on human chromosome 2p13.3. PCBP1 is known as a cytosolic iron chaperone

Synthetic peptide directed towards the middle region of Human PCBP1

Poly(rC) binding protein 1 (PCBP1) appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5′-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. PCBP1 is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This intron less gene is thought to be generated by retro transposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 has paralogues PCBP3 and PCBP4 which is thought to arose as a result of duplication events of entire genes.
PCBP1 functions as a tumor suppressor in prostate epithelial cells by blocking MAPK1 (Mitogen-activated protein kinase 1) expression. It is a potential therapeutic target for colorectal cancer. Mutations in PCBP1 is linked to Burkitt lymphoma. PCBP1 transports iron to ferritin. It also acts a tumor suppressor.

Synthetic peptide located within the following region: PHATHDLEGPPLDAYSIQGQHTISPLDLAKLNQVARQQSHFAMMHGGTGF

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

rabbit

100

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous solution

37 kDa

guinea pig, bovine, mouse, horse, dog, human, rabbit, rat

0.5-1 mg/mL

immunoblotting: suitable
immunohistochemistry: suitable

NM_006196

Q15365

wet ice

−20℃

human ... PCBP1(5093)

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12 - Non Combustible Liquids

WGK 3