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Anti-NDRG3 antibody produced in rabbit

产品编号:3379693
规格:affinity isolated antibody
包装规格:100 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
3379693100 μG5040
产品别名

Anti-NDRG3 antibody produced in rabbit

Protein NDRG3

基本信息
NACRES
NA.41
General description【一般描述】
NDRG3 (N-myc downstream-regulated gene 3 protein) is a novel member of N-myc down-regulated gene (NDRG) family mapped to human chromosomal location 20q11.21-q11.23. It is abundantly expressed in brain, prostate, ovary, and testis tissues. It is localized to the outer layers of seminiferous epithelium.
Immunogen【免疫原】
The antiserum was produced against synthesized peptide derived from human NDRG3.

Immunogen Range: 206-255
Application【应用】
Anti-NDRG3 antibody produced in rabbit is suitable for immunohistochemistry and western blot.
Biochem/physiol Actions【生化/生理作用】
N-myc downstream-regulated gene 3 protein (NDRG3) is involved in prostate cancer cell growth in vitro and in vivo. It acts as an androgen regulated and prostate enriched gene during controlling of cancer cell growth. Thus, overexpression of NDRG3 has been linked to the malignant phenotype of tumors. In hepatitis B virus (HBV)-related hepatocellular carcinoma cell line, NDRG3 gene is inversely expressed with the miR-122 expression. Thus, it has been reported that in conjugation with miR-122, NDRG3 can be a potential therapeutic marker for hepatocellular carcinoma (HCC). Prominent localization of NDRG3 in the epithelium cells indicate its role in spermatogenesis. It also plays an important role in lactate-induced hypoxia signaling pathway in hypoxia. Its protein level expression in cell is negatively regulated by oxygen, whereas, whereas excess lactate produced under prolonged hypoxia blocks its proteasomal degradation by binding to NDRG3.
Features and Benefits【特点和优势】
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form【外形】
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
100
conjugate【偶联物】
unconjugated
antibody form【抗体形式】
affinity isolated antibody
antibody product type
primary antibodies
clone【克隆】
polyclonal
form【形式】
buffered aqueous solution
mol wt【分子量】
antigen 41 kDa
species reactivity
rat, human, mouse
concentration【浓度】
~1 mg/mL
technique(s)
ELISA: 1:40000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.【NCBI登记号】
Q9UGV2
UniProt accession no.【UniProt登记号】
Q9UGV2
shipped in【运输】
wet ice
storage temp.【储存温度】
−20℃
Gene Information
human ... NDRG3(57446)
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
nwg
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