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Anti-NDE1 antibody produced in rabbit

产品编号:3379656
规格:affinity isolated antibody
包装规格:100 μL
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
3379656100 μL6300
产品别名

Anti-NDE1 antibody produced in rabbit

Anti-nudE Nuclear distribution gene E homolog 1 (A. nidulans)

Anti-FLJ20101

Anti-NUDE

Anti-HOM-TES-87

Anti-NUDE1

基本信息
NACRES
NA.41
General description【一般描述】
NDE1 codes for a protein that belongs to the nuclear distribution E (NudE) family. It forms a part of a multiprotein complex that modulates the function of dynein. Phoshorylated NDE1 is known to interact with NDEL1 and LIS1. NDE1 represses ciliogenesis and modulates cell cycle re-entry. Mutations in NDE1 have been linked to microcephaly with lissencephaly.
Rabbit Anti-NDE1 antibody recognizes chicken, human, mouse, rat, rabbit, zebrafish, bovine, and canine NDE1.
Immunogen【免疫原】
Synthetic peptide directed towards the middle region of human NDE1
Application【应用】
Rabbit Anti-NDE1 antibody is suitable for western blot applications at a concentration of 1μg/ml.
Biochem/physiol Actions【生化/生理作用】
NDE1 is required for centrosome duplication and formation and function of the mitotic spindle. It is essential for the development of the cerebral cortex. NDE1 may regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post-mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex
Sequence【序列】
Synthetic peptide located within the following region: AHRGPSSSLNTPGSFRRGLDDSTGGTPLTPAARISALNIVGDLLRKVGAL
Physical form【外形】
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
100
conjugate【偶联物】
unconjugated
antibody form【抗体形式】
affinity isolated antibody
antibody product type
primary antibodies
clone【克隆】
polyclonal
form【形式】
buffered aqueous solution
mol wt【分子量】
38 kDa
species reactivity
rabbit, guinea pig, human, dog, mouse, bovine, horse, rat
concentration【浓度】
0.5 mg - 1 mg/mL
technique(s)
western blot: suitable
NCBI accession no.【NCBI登记号】
NP_001137451
UniProt accession no.【UniProt登记号】
Q9NXR1-2
shipped in【运输】
wet ice
storage temp.【储存温度】
−20℃
Gene Information
human ... NDE1(54820)
产品说明
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 3
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