Anti-MELK antibody produced in rabbit

NA.41

Maternal embryonic leucine zipper kinase (MELK) is a serine/threonine kinase that exists in bi-lobal conformation. Structurally, MELK comprises an N-terminal catalytic domain, ubiquitin-associated (UBA) domain, and a kinase domain. The MELK gene is mapped to human chromosome location 9p13.2.The MELK antibody detects endogenous levels of total MELK protein.

Peptide sequence around aa. 626-630 (I-R-R-Q-R), according to the protein NP_055606.1

Anti-MELK antibody produced in rabbit has been used in western blotting at a dilution of 1:1000.

Maternal embryonic leucine zipper kinase (MELK) participates in cell cycle regulation by interacting with cell cycle proteins. It may have a role in malignant cell survival and cancer stem cell growth. An elevated expression of MELK is observed in triple-negative breast cancer, glioblastoma multiforme(GBM), and astrocytomas.

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Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

rabbit

100

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous solution

~74 kDa

human, rat, mouse

1 mg/mL

western blot: 1:500-1:1000

IgG

(I-R-R-Q-R)

NM_014791.2

Q14680

wet ice

−20℃

human ... MELK(9833)

Phosphorylates ZNF622 and may contribute to its redirection to the nucleus. May be involved in the inhibition of spliceosome assembly during mitosis.

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12 - Non Combustible Liquids

WGK 1