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抗 MDM2 兔抗
Anti-MDM2 antibody produced in rabbit
产品别名
抗 MDM2 兔抗
Anti-MDM2 antibody produced in rabbit
Oncoprotein Mdm2
p53-binding protein Mdm2
Double minute 2 protein
HDM2
Ubiquitin-protein ligase E3 Mdm2
基本信息
| MDL number | MFCD00282354 |
| NACRES | NA.41 |
| General description【一般描述】 | Anti-MDM2 antibody detects endogenous levels of total MDM2 protein. Murine double minute 2 (MDM2) is an oncogenic protein. It is an E3 ubiquitin-protein ligase, that is mapped to human chromosome 12q15. |
| Immunogen【免疫原】 | The antiserum was produced against synthesized peptide derived from human MDM2. Immunogen Range: 132-181 |
| Application【应用】 | Anti-MDM2 antibody has been used in immunohistochemistry. |
| Biochem/physiol Actions【生化/生理作用】 | Murine double minute 2 (MDM2) is a negative regulator of the p53 tumor suppressor. It regulates cell cycle, cellular differentiation, cell fate determination, DNA repair and transcription. Epithelial-mesenchymal transition and metastasis of ovarian cancer SKOV3 cells are induced by MDM2. |
| Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| Physical form【外形】 | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
产品性质
| biological source【生物来源】 | rabbit |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen 55 kDa |
| species reactivity | human, mouse |
| concentration【浓度】 | ~1 mg/mL |
| technique(s) | ELISA: 1:1000 immunofluorescence: 1:100-1:500 western blot: 1:500-1:1000 |
| NCBI accession no.【NCBI登记号】 | Q00987 |
| UniProt accession no.【UniProt登记号】 | Q00987 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... MDM2(4193) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | nwg |
