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Anti-Lin28 antibody produced in rabbit
产品别名
Anti-Lin28 antibody produced in rabbit
Anti-CSDD1
Anti-LIN28A
Anti-LIN-28
Anti-ZCCHC1
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | The Lin28 (lin-28 homolog A) gene encodes RNA-binding protein, and is located on human chromosome 1p36. The antibody detects endogenous levels of total Lin28 protein. |
| Immunogen【免疫原】 | Peptide sequence around aa. 1-5 (M-G-S-V-S), according to the protein NP_078950.1 |
| Biochem/physiol Actions【生化/生理作用】 | The Lin28 (lin-28 homolog A) protein participates in several biological processes like development, reprogramming, differentiation, pluripotency and glucose metabolism.{19, 20} It plays an important role in immunity. |
| Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| Physical form【外形】 | Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | ~26 kDa |
| species reactivity | mouse, human, rat |
| concentration【浓度】 | 1 mg/mL |
| technique(s) | western blot: 1:500-1:1000 |
| isotype【同位素/亚型】 | IgG |
| immunogen sequence【免疫原序列】 | (M-G-S-V-S) |
| NCBI accession no.【NCBI登记号】 | NM_024674.4 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... Lin28(79727) |
产品说明
| Target description【目标描述】 | Acts as a ′translational enhancer′, driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression. Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 1 |
