Anti-LIMP2 antibody produced in rabbit

NA.41

Lysosomal integral membrane protein type 2 (LIMP2) is an N-glycosylated type III transmembrane protein. It is composed of a lumenal domain, two transmembrane domains, and a cytoplasmic domain. LIMP2 belongs to the CD36 family of scavenger receptor proteins and is found abundantly in the lysosome. The LIMP2 gene is located on the human chromosome at 4q21.1.

LIMP2 antibody was raised against a 16 amino acid peptide from near the center of human LIMP2.

Anti-LIMP2 antibody produced in rabbit has been used in immunofluorescence (1:100) and western blotting.

Lysosomal integral membrane protein type 2 (LIMP2) binds to β-glucocerebrosidase. Mutations in the LIMP 2 gene are associated with action myoclonus-renal failure syndrome, a fatal autosomal recessive disorder. Higher levels of LIMP2 lead to enlargement of early or late endosomes/lysosomes. Overexpression of LIMP2 is associated with impairment of endocytotic membrane trafficking.

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The action of this antibody can be blocked using blocking peptide SBP3500449.

Supplied in PBS with 0.02% sodium azide.

rabbit

100

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous solution

predicted mol wt 53 kDa

human, rat, mouse

immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

AAH21892

Q14108

dry ice

−20℃

human ... SCARB2(950)

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12 - Non Combustible Liquids

WGK 2