Anti-Lamin A-Atto 647N antibody produced in rabbit

MFCD01633588

Lamin A is a structural protein of the nuclear lamina. The nuclear lamina is a meshwork of intermediate filaments that underlies the inner face of the nuclear envelope. The precursor of lamin A, prelamin comprises 98 unique amino acids and also harbors the farnesyl group in C-terminus post-synthesis. The cleavage of the farnesyl group containing end 18 amino acids results in mature Lamin A. Lamin A is mapped to human chromosome 1q21.2.

Anti-Lamin A-Atto 647N recognizes human Lamin A.

Anti-Lamin A−Atto 647N antibody produced in rabbit may be used in direct immunofluorescence.

Lamin A is cleaved into a 47 kDa fragment during apoptosis. Lamin A cleavage seems to be essential for chromatin condensation and nuclear disassembly in apoptosis. Mutations in Lamin A and C have been linked to a variety of rare human diseases including muscular dystrophy, lipodystrophy, cardiomyopathy, neuropathy and progeroid syndromes (collectively termed laminopathies) and to premature aging (Hutchinson-Gilford progeria syndrome).

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

rabbit

200

Atto 647N conjugate

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous solution

human

1.5-3 mg/mL

direct immunofluorescence: 5-10 μg/mL using human HeLa cells

P02545

dry ice

−20℃

human ... LMNA(4000)

For continuous use, store at 2–8 ℃ for up to one month. For extended storage, freeze in working aliquots. Protect from prolonged exposure to light. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

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12 - Non Combustible Liquids

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)