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Anti-ITGB3 (Ab-773) antibody produced in rabbit

产品编号:3370598
规格:affinity isolated antibody
包装规格:100 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
3370598100 μG5040
产品别名

Anti-ITGB3 (Ab-773) antibody produced in rabbit

Anti-GP3A antibody produced in rabbit

Anti-GPIIIa antibody produced in rabbit

Anti-CD61 antibody produced in rabbit

Anti-integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) antibody produced in rabbit

基本信息
MDL number
MFCD00211790
NACRES
NA.41
General description【一般描述】
ITGB3 (integrin subunit β3) codes for integrin αIIbβ3. It is located on human chromosome 17q21.31-32.
Immunogen【免疫原】
Peptide sequence around aa. 771-775 (P-L-Y-K-E), according to the protein ITGB3.
Biochem/physiol Actions【生化/生理作用】
Mutations in ITGB3 (integrin subunit β3) results in Glanzmann thrombasthenia (GT). It plays a major role in the movement and attack of colorectal cancer cells, promoted by reactive oxygen species.
Features and Benefits【特点和优势】
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form【外形】
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
100
conjugate【偶联物】
unconjugated
antibody form【抗体形式】
affinity isolated antibody
antibody product type
primary antibodies
clone【克隆】
polyclonal
form【形式】
buffered aqueous solution
mol wt【分子量】
~110 kDa
species reactivity
rat, human, mouse
concentration【浓度】
1 mg/mL
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
western blot: 1:500-1:1000
isotype【同位素/亚型】
IgG
immunogen sequence【免疫原序列】
(P-L-Y-K-E)
NCBI accession no.【NCBI登记号】
NP_000203.2
UniProt accession no.【UniProt登记号】
P05106
shipped in【运输】
wet ice
storage temp.【储存温度】
−20℃
Gene Information
human ... ITGB3(3690)
产品说明
Target description【目标描述】
Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 1
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