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Anti-Interleukin-4 Soluble Receptor antibody produced in goat

产品编号:3370119
规格:IgG fraction of antiserum, lyophilized powder
包装规格:1 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
33701191 MG4730
产品别名

Anti-Interleukin-4 Soluble Receptor antibody produced in goat

Anti-IL-4 sR

基本信息
MDL number
MFCD02096774
NACRES
NA.41
General description【一般描述】
Interleukin-4 (IL-4) is a T cell derived chemokine that stimulates the Th2 mediated immune response and proliferation of B cells. The effects of IL-4 are mediated by two types of receptors, type I receptor consisting of IL-4Rα and common γ chain and type II receptor composed of IL-4Rα and IL-13Rα1. The signalling stimulated by IL-4R leads to activation of JAK/STAT6 and IRS-mediated PI3K/Akt pathway. Through these pathways, IL-4 is responsible for endocytic activity of macrophages, chemotaxis of leukocytes in response to inflammation, angiogenesis and regulation of nitric oxide metabolism in macrophages. Anti-tumor effects of IL-4R signaling have been reported in cancers of breast, liver and renal cells
Anti-Interleukin-4 soluble receptor specifically recognizes human cell surface IL-4R.
Specificity【特异性】
The antibody will neutralize human cell surface IL-4 receptor mediated-bioactivity.
Immunogen【免疫原】
recombinant human IL-4 soluble receptor (IL-4 sR), expressed in Sf 21 insect cells.
Application【应用】
Anti-Interleukin-4 soluble receptor antibody may be used for immunoblotting at a working concentration of 1-2 μg/ml. For ELISA, a working concentration of 0.5-1.0 μg/ml is recommended. The antibody is suitable for neutralization reactions at a working concentration of 5-10 μg/ml. This antibody was used for immunostaining of parasympathetic neurons from guinea pig and human neuroblastoma cells at a dilution of 1:200.
Physical form【外形】
Lyophilized from 51.5 μL of a 0.2μm filitered solution in PBS (pH7.4) with 5% trehalose.
Preparation Note【制备说明】
Purified using Protein G.
产品性质
Quality Level【质量水平】
100
biological source【生物来源】
goat
conjugate【偶联物】
unconjugated
antibody form【抗体形式】
IgG fraction of antiserum
antibody product type
primary antibodies
clone【克隆】
polyclonal
form【形式】
lyophilized powder
species reactivity
human
technique(s)
indirect ELISA: suitable
neutralization: suitable
western blot: suitable
UniProt accession no.【UniProt登记号】
P24394
storage temp.【储存温度】
−20℃
Gene Information
human ... IL4R(3566)
安全信息
Storage Class Code【储存分类代码】
10 - Combustible liquids
WGK
WGK 1
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