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Anti-Interleukin-4 Soluble Receptor antibody produced in goat
产品编号: | 3370119 |
规格: | IgG fraction of antiserum, lyophilized powder |
包装规格: | 1 MG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
Anti-Interleukin-4 Soluble Receptor antibody produced in goat
Anti-IL-4 sR
基本信息
MDL number | MFCD02096774 |
NACRES | NA.41 |
General description【一般描述】 | Interleukin-4 (IL-4) is a T cell derived chemokine that stimulates the Th2 mediated immune response and proliferation of B cells. The effects of IL-4 are mediated by two types of receptors, type I receptor consisting of IL-4Rα and common γ chain and type II receptor composed of IL-4Rα and IL-13Rα1. The signalling stimulated by IL-4R leads to activation of JAK/STAT6 and IRS-mediated PI3K/Akt pathway. Through these pathways, IL-4 is responsible for endocytic activity of macrophages, chemotaxis of leukocytes in response to inflammation, angiogenesis and regulation of nitric oxide metabolism in macrophages. Anti-tumor effects of IL-4R signaling have been reported in cancers of breast, liver and renal cells Anti-Interleukin-4 soluble receptor specifically recognizes human cell surface IL-4R. |
Specificity【特异性】 | The antibody will neutralize human cell surface IL-4 receptor mediated-bioactivity. |
Immunogen【免疫原】 | recombinant human IL-4 soluble receptor (IL-4 sR), expressed in Sf 21 insect cells. |
Application【应用】 | Anti-Interleukin-4 soluble receptor antibody may be used for immunoblotting at a working concentration of 1-2 μg/ml. For ELISA, a working concentration of 0.5-1.0 μg/ml is recommended. The antibody is suitable for neutralization reactions at a working concentration of 5-10 μg/ml. This antibody was used for immunostaining of parasympathetic neurons from guinea pig and human neuroblastoma cells at a dilution of 1:200. |
Physical form【外形】 | Lyophilized from 51.5 μL of a 0.2μm filitered solution in PBS (pH7.4) with 5% trehalose. |
Preparation Note【制备说明】 | Purified using Protein G. |
产品性质
Quality Level【质量水平】 | 100 |
biological source【生物来源】 | goat |
conjugate【偶联物】 | unconjugated |
antibody form【抗体形式】 | IgG fraction of antiserum |
antibody product type | primary antibodies |
clone【克隆】 | polyclonal |
form【形式】 | lyophilized powder |
species reactivity | human |
technique(s) | indirect ELISA: suitable neutralization: suitable western blot: suitable |
UniProt accession no.【UniProt登记号】 | P24394 |
storage temp.【储存温度】 | −20℃ |
Gene Information | human ... IL4R(3566) |
安全信息
Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
WGK | WGK 1 |