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Anti-ICAD antibody produced in rabbit
| 产品编号： | 3369013 |
| 规格： | affinity isolated antibody, buffered aqueous solution |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-ICAD antibody produced in rabbit
Anti-DNA fragmentation factor, α-subunit
Anti-DFF45
基本信息
| MDL number | MFCD02096208 |
| NACRES | NA.41 |
| General description【一般描述】 | The gene DNA fragmentation factor subunit α (DFFA) is mapped to human chromosome 1p36.2. The encoded protein localizes to the chromatin fraction. It exist in association with DFF40, thereby forming a heterodimer. DFFA is popularly called as DFF45 (DNA fragmentation factor 45). |
| Immunogen【免疫原】 | a peptide corresponding to amino acids 312-331 of mouse ICAD. |
| Biochem/physiol Actions【生化/生理作用】 | DNA fragmentation factor subunit α (DFFA) is a component of DNA fragmentation factor (DFF). It is mainly associated with apoptosis and genomic stability. Caspase-3-mediated cleavage of DFFA releases DFF40 (DNA fragmentation factor 40) which degrades chromosomal DNA. During menstruation, the apoptosis of endometrium cells is associated with DFFA. Its expression decreases after menopause. Silencing of DFFA increases doxorubicin effects in breast cancer cells. |
| Linkage【联系】 | The action of this antibody can be blocked using blocking peptide SBP2003. |
| Physical form【外形】 | Solution in phosphate buffered saline containing 0.02% sodium azide |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | predicted mol wt 45 kDa |
| species reactivity | mouse |
| technique(s) | immunofluorescence: suitable immunohistochemistry: suitable indirect ELISA: suitable western blot: suitable |
| UniProt accession no.【UniProt登记号】 | O54786 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | mouse ... Dffa(13347) |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
