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Anti-Histone Deacetylase 11 (HDAC11) antibody produced in rabbit
| 产品编号： | 3367630 |
| 规格： | ~1 mg/mL, affinity isolated antibody, buffered aqueous solution |
| 包装规格： | 200 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-Histone Deacetylase 11 (HDAC11) antibody produced in rabbit
Anti-HD11
Anti-HDAC11
基本信息
| MDL number | MFCD06202148 |
| NACRES | NA.41 |
| General description【一般描述】 | Anti-Histone Deacetylase 11 (HDAC11) is developed in rabbit using a synthetic peptide corresponding to amino acid residues 2-16 of human HDAC11 with an N-terminal added cysteine, conjugated to KLH, as immunogen. Histone deacetylase 11 (HDAC11) belongs to the class IV member of the histone deacetylase (HDAC) family. It is mainly expressed in brain, heart, skeletal muscle, kidney, testis, immune cells and cancer cells. HDAC11 has a molecular weight of 39 kDa. The protein consists of one catalytic domain and is found in a complex with HDAC6. This gene is mapped to human chromosome 3p25. |
| Immunogen【免疫原】 | synthetic peptide corresponding to amino acids 2-16 of human HDAC11 with an N-terminal added cysteine, conjugated to KLH. The corresponding sequence differs by three amino acids in both rat and mouse HDAC11. |
| Application【应用】 | Anti-Histone Deacetylase 11 (HDAC11) antibody produced in rabbit has been used in chromatin immunoprecipitation (ChIP) and western blotting analysis. |
| Biochem/physiol Actions【生化/生理作用】 | Histone acetylation is a dynamic process whose levels are determined by the net activities of HATs and the competing enzymes histone deacetylases (HDACs). Histone Deacetylase 11 (HDAC11) modulates immune activation and tumorigenesis. It negatively controls the synthesis of interleukin-10 (IL-10) in antigen-presenting cells (APCs). It also modulates type I interferon (IFN) signalling. |
| Physical form【外形】 | Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 200 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen ~39 kDa |
| species reactivity | mouse, human |
| concentration【浓度】 | ~1 mg/mL |
| technique(s) | western blot (chemiluminescent): 0.5-1 μg/mL using extracts of mouse brain western blot (chemiluminescent): 4-6 μg/mL using nuclear extracts of HeLa cells. |
| UniProt accession no.【UniProt登记号】 | Q96DB2 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... HDAC11(79885) mouse ... Hdac11(232232) rat ... Hdac11(297453) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
