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Anti-GRIN1 (Ab-897) antibody produced in rabbit
产品别名
Anti-GRIN1 (Ab-897) antibody produced in rabbit
Anti-NMDA1 antibody produced in rabbit
Anti-NR1 antibody produced in rabbit
Anti-glutamate receptor, ionotropic, N-methyl D-aspartate 1 antibody produced in rabbit
Anti-NMDAR1 antibody produced in rabbit
基本信息
| MDL number | MFCD00282329 |
| NACRES | NA.41 |
| Immunogen【免疫原】 | Peptide sequence around aa. 895-899 (R-S-S-K-D), according to the protein GRIN1. |
| Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| Physical form【外形】 | Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | ~120 kDa |
| species reactivity | rat, mouse, human |
| concentration【浓度】 | 1 mg/mL |
| technique(s) | indirect immunofluorescence: 1:100-1:200 |
| isotype【同位素/亚型】 | IgG |
| immunogen sequence【免疫原序列】 | (R-S-S-K-D) |
| NCBI accession no.【NCBI登记号】 | NP_000823.4 |
| UniProt accession no.【UniProt登记号】 | Q05586 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... GRIN1(2902) |
产品说明
| Target description【目标描述】 | NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and AMPA receptors. NMDA receptors consist of NR1 subunits combined with one or more NR2 (A-D) or NR3 (A-B) subunits. The ligand-gated channel is permeable to cations including Ca2+, and at resting membrane potentials NMDA receptors are inactive due to a voltage-dependent blockade of the channel pore by Mg2+. NMDA receptor activation, which requires binding of glutamate and glycine, leads to an influx of Ca2+ into the postsynaptic region where it activates several signaling cascades, including pathways leading to the induction of long-term potentiation (LTP) and depression (LTD). NMDA receptors have a critical role in excitatory synaptic transmission and plasticity in the CNS. They govern a range of physiological conditions including neurological disorders caused by excitotoxic neuronal injury, psychiatric disorders and neuropathic pain syndromes. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 1 |
