Anti-FMN1 antibody produced in rabbit

HPA005465    Human Protein Atlas characterization data

Formin-1 (FMN1) belongs to the family of non-FDD type formin homology proteins. This gene is localized to chromosome 15q13.3, and produces two FMN1 isoforms- FMN1isoform 1 and FMN1 isoform 2. This is a result of alternate splicing of the alternative promoter type. This protein consists of FH1, FH2, FMH1 and FMH2 domains.

FMN1_HUMAN Isoform 2 of Q68DA7 - Homo sapiens recombinant protein epitope signature tag (PrEST)

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.

Formin-1 (FMN1) is responsible for the polymerization of actin filaments. It interacts with α-catenin and moves to nascent adherens junctions, where it nucleates actin filaments. Thus, it plays an essential role in the formation of cell-cell junctions by mediating adherens junction formation. Mutations in this gene in mouse, give rise to recessively inherited murine limb deformity, which is characterized by limb deformity or renal aplasia. Studies have shown that mutation in FMN1 gene in humans gives rise to oligosyndactyly, renal defects, radioulnar synostosis and hearing loss. This phenotype is similar to mice limb deformity. Duplication in this gene has been found in a patient with Cenani-Lenz-like oligosyndactyly of the hands.

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Corresponding Antigen APREST70053.

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

Prestige Antibodies is a registered trademark of sigma-aldrich Co. LLC

rabbit

100

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

Prestige Antibodies^® Powered by Atlas Antibodies

buffered aqueous glycerol solution

human

antibody small pack of 25 μL

immunohistochemistry: 1:200- 1:500

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Q68DA7

wet ice

−20℃

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12 - Non Combustible Liquids

WGK 1