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Anti-ESR1 (Ab-167) antibody produced in rabbit
产品别名
Anti-ESR1 (Ab-167) antibody produced in rabbit
Anti-DKFZp686N23123 antibody produced in rabbit
Anti-ER antibody produced in rabbit
Anti-estrogen receptor 1 antibody produced in rabbit
Anti-ESRA antibody produced in rabbit
Anti-ESR antibody produced in rabbit
产品性质
| biological source【生物来源】 | rabbit |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | ~66 kDa |
| species reactivity | human |
| concentration【浓度】 | 1 mg/mL |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100 indirect immunofluorescence: 1:100-1:200 western blot: 1:500-1:1000 |
| isotype【同位素/亚型】 | IgG |
| immunogen sequence【免疫原序列】 | (L-A-S-T-N) |
| NCBI accession no.【NCBI登记号】 | NP_000116.2 |
| UniProt accession no.【UniProt登记号】 | P03372 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... ESR1(2099) |
基本信息
| General description【一般描述】 | The estrogen receptor 1 (ESR1) gene is mapped to human chromosome 6q25.1-q25.2. The encoded protein belongs to the nuclear hormone receptor family. ESR1 is characterized with a transcription activation function-1 domain (AF-1), a DNA-binding domain (DBD), a hinge domain and a ligand-binding domain (LBD/AF-2). |
| Immunogen【免疫原】 | Peptide sequence around aa. 165-169 (L-A-S-T-N), according to the protein ESR1. |
| Biochem/physiol Actions【生化/生理作用】 | Estrogen receptor 1 (ESR1) is involved in immune and inflammatory response. Aberrations in ESR1 results in Mayer-Rokitansky-Küster-Hauser syndrome that is associated with the congenital absence of the uterus and the upper two-thirds of the vagina. Polymorphism in the gene increases the risk of susceptibility to fractures. Elevated expression of the gene has been observed in breast cancer patients. |
| Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| Physical form【外形】 | Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol |
产品说明
| Target description【目标描述】 | Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 1 |
