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抗-ERGIC2 兔抗
Anti-ERGIC2 antibody produced in rabbit
产品别名
抗-ERGIC2 兔抗
Anti-ERGIC2 antibody produced in rabbit
Anti-ERGIC and golgi 2
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | ERGIC and Golgi 2 (ERGIC2) is a protein with an unknown function that shows sequence homology with proteins involved in ER/Golgi vesicle trafficking. ERGIC2 has been shown to interact with the brain specific calcium sensor otoferlin which is involved in calcium-dependent vesicle fusion. |
| Specificity【特异性】 | Anti-ERGIC2 polyclonal antibody reacts with human, mouse, rat, zebrafish, chicken, bovine, and canine ERGIC and Golgi 2 proteins. |
| Immunogen【免疫原】 | Synthetic peptide directed towards the N terminal region of human ERGIC2 |
| Application【应用】 | Anti-ERGIC2 polyclonal antibody is used to tag ERGIC and Golgi 2 proteins for detection and quantitation by Western blotting and in cells and tissues by immunohistochemical (IHC) techniques. It is used as a probe to study the possible roles of ERGIC and Golgi 2 in vesicle fusion and endoplasminc reticulum (ER) to Golgi trafficking. |
| Biochem/physiol Actions【生化/生理作用】 | ERGIon Channel2 possibly play role in transport between endoplasmic reticulum and Golgi. ERGIon Channel2 is downregulated in prostate cancer. ERGIon Channel2 may play an important role in the growth and tumorigenicity of PC-3 prostate tumor cells. Ectopic expression of a partial sequence of ERGIon Channel2 as a VP22-fusion protein in prostate cancer cell line, PC-3, induced cellular senescence. Interferon-beta (IFN-beta) and a number of IFN-inducible genes were upregulated by the ERGIon Channel2-VP22 fusion protein. |
| Sequence【序列】 | Synthetic peptide located within the following region: MRRLNRKKTLSLVKELDAFPKVPESYVETSASGGTVSLIAFTTMALLTIM |
| Physical form【外形】 | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | 43 kDa |
| species reactivity | bovine, human |
| concentration【浓度】 | 0.5 mg - 1 mg/mL |
| technique(s) | western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_057654 |
| UniProt accession no.【UniProt登记号】 | Q96RQ1 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... ERGIC2(51290) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
