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Anti-DCLK1 antibody produced in rabbit

产品编号:3356758
规格:~1.5 mg/mL, affinity isolated antibody
包装规格:200 μL
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
3356758200 μL6150
产品别名

Anti-DCLK1 antibody produced in rabbit

Anti-DCAMKL1

Anti-DCLK

Anti-doublecortin and CaM kinase-like 1

Anti-DCDC3A

基本信息
NACRES
NA.44
General description【一般描述】
DCLK1 is a neuronal transmembrane enzyme that may regulate cortical development, nerve cell migration and microtubule polymerization. This enzyme is similar to DCX, but DCLK1 additionally functions as a Ca2+/calmodulin-dependent protein kinase that can phosphorylate myelin basic protein and itself . Anti-DCLK1 antibody is specific for human, rat and mouse DCLK1. In immunoblotting, detection of the DCLK1 band is specifically inhibited by the DCLK1 immunizing peptide.
Anti-DCLK1 is produced in rabbit using as immunogen a synthetic peptide corresponding to human DCLK1, conjugated to KLH. DCLK1 (doublecortin like kinase 1) is also known as DCLK, DCAMKL1, DCDC3A and CLICK1. DCLK1 consists of an N-terminal doublecortin (DC) domain, responsible for its localization to microtubules and a C-terminal Ser/Thr kinase domain.
Immunogen【免疫原】
The corresponding sequence is highly conserved (single amino acid substitution) in rat and mouse DCLK1.
Application【应用】
Anti-DCLK1 antibody is suitable for use in western blot (1.5-3.0 μg/mL using extracts of postnatal mouse brain (S1 fraction), postnatal rat brain (S1 fraction) and HEK-293T cells over-expressing human DCLK1). The antibody may also be used for immunoblot (approx. 81 kDa) assays.
Biochem/physiol Actions【生化/生理作用】
Doublecortin-like kinase1 (DCLK1) is widely expressed in post-mitotic neurons in the developing nervous system and important for neuronal migration to cerebral cortex. DCLK1 is highly expressed during embryogenesis and is localized to neuronal growth cones where it associates with the microtubule cytoskeleton and regulates microtubule polymerization. DCLK1 kinase domain is susceptible to cleavage by the Ca2+ -dependent protease calpain, suggesting that a Ca2+ -responsive mechanism is involved in regulating the DCLK1 kinase activity during embryogenesis. DCLK1 has been identified as a putative intestinal stem cell marker.
Physical form【外形】
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide
产品性质
biological source【生物来源】
rabbit
conjugate【偶联物】
unconjugated
antibody form【抗体形式】
affinity isolated antibody
antibody product type
primary antibodies
clone【克隆】
polyclonal
form【形式】
buffered aqueous solution
mol wt【分子量】
~81 kDa
species reactivity
human, mouse, rat
concentration【浓度】
~1.5 mg/mL
technique(s)
western blot: 1.5-3.0 μg/mL using extracts of postnatal mouse brain (S1 fraction), postnatal rat brain (S1 fraction) and of HEK-293T cells over-expressing human DCLK1
UniProt accession no.【UniProt登记号】
O15075
shipped in【运输】
dry ice
storage temp.【储存温度】
−20℃
Gene Information
human ... DCLK1(9201)
mouse ... Dclk1(13175)
rat ... Dclk1(83825)
产品说明
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
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