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Anti-CYSLTR1 antibody produced in rabbit

产品编号:3356399
规格:Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
包装规格:100 μL
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
3356399100 μL5840
产品别名

Anti-CYSLTR1 antibody produced in rabbit

Anti-Cysteinyl leukotriene receptor 1 antibody produced in rabbit

Anti-Cysteinyl leukotriene D4 receptor antibody produced in rabbit

Anti-LTD4 receptor antibody produced in rabbit

Anti-HMTMF81 antibody produced in rabbit

Anti-HG55 antibody produced in rabbit

基本信息
Human Protein Atlas Number【人类蛋白质图谱编号】
HPA010546    Human Protein Atlas characterization data
General description【一般描述】
CYSLTR1 (cysteinyl leukotriene receptor 1) is a GPCR (G-protein couple receptor), which functions as a receptor for CysLTs, such as, LTC4 (leukotriene C4), LTD4, and LTE4. This receptor is expressed by epithelial cells, and translocates to nucleus from cell membrane in a ligand-dependent manner. It also resides in the cytoplasm.
Immunogen【免疫原】
Cysteinyl leukotriene receptor 1 recombinant protein epitope signature tag (PrEST)
Application【应用】
All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem/physiol Actions【生化/生理作用】
CYSLTR1 (cysteinyl leukotriene receptor 1) participates in inflammatory processes, and its antagonists are used in the treatment of bronchial asthma. It also regulates vascular permeability and is involved in ischemic brain injury. It elicits elevation in blood-brain barrier permeability, and thus, brain edema and ischemia. In house dust mite-allergic individuals, the expression of CYSLTR1 by T-cells is increased in a IL-4-dependent manner, when sensitized by Dermatophagoides pteronyssinus allergen. Its expression is also linked with bronchial inflammation in COPD (chronic obstructive pulmonary disorder) patients with severe exacerbations. This receptor might be involved in the pathogenesis of adenoid hypertrophy, as it is highly expressed in the adenoid tissues of children with AH. Studies in Chinese children show that the expression level of this receptor in upper-airway tonsillar tissues determines the severity of sleep-disordered breathing (SDB).
Features and Benefits【特点和优势】
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.
Linkage【联系】
Corresponding Antigen APREST74425.
Physical form【外形】
Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide
Legal Information【法律信息】
Prestige Antibodies is a registered trademark of sigma-aldrich Co. LLC
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
100
conjugate【偶联物】
unconjugated
antibody form【抗体形式】
affinity isolated antibody
antibody product type
primary antibodies
clone【克隆】
polyclonal
product line【产品线】
Prestige Antibodies® Powered by Atlas Antibodies
form【形式】
buffered aqueous glycerol solution
species reactivity
human
technique(s)
immunoblotting: 0.04-0.4 μg/mL
immunohistochemistry: 1:200-1:500
immunogen sequence【免疫原序列】
RLSTFRKHSLSSVTYVPRKKASLPE
UniProt accession no.【UniProt登记号】
Q9Y271
shipped in【运输】
wet ice
storage temp.【储存温度】
−20℃
Gene Information
human ... CYSLTR1(10800)
产品说明
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
10 - Combustible liquids
WGK
WGK 1
Personal Protective Equipment【个人防护装备】
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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