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Anti-CYCLIN D1, C-Terminal antibody produced in rabbit
产品别名
Anti-CYCLIN D1, C-Terminal antibody produced in rabbit
G1/S-specific cyclin D1
CYL-1
cyclin D1
BCL-1 oncogene
BCL1
基本信息
| MDL number | MFCD00239664 |
| NACRES | NA.41 |
| General description【一般描述】 | The CCND1 (cyclin D1) gene is mapped to human chromosome 11q13.3. Anti-CYCLIN D1 antibody detects endogenous levels of total CYCLIN D1 protein. |
| Immunogen【免疫原】 | The antiserum was produced against synthesized peptide derived from human Cyclin D1. Immunogen Range: 246-295 |
| Application【应用】 | Anti-CYCLIN D1, C-Terminal antibody produced in rabbit has been used in western blotting analysis. |
| Biochem/physiol Actions【生化/生理作用】 | CCND1 (cyclin D1) regulates cell cycle by mediating the G1 to S phase transition. The gene gets activated by β-catenin and participates in the process of tumor formation. Upregulation of the gene is observed in cancer such as lung, breast, colon, hematopoietic and prostate carcinomas, and promotes contact independent cell growth. Variation in CCND1 contributes to increased occurrence of colorectal cancer. |
| Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| Physical form【外形】 | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
产品性质
| biological source【生物来源】 | rabbit |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen 33 kDa |
| species reactivity | rat, mouse, human |
| concentration【浓度】 | ~1 mg/mL |
| technique(s) | ELISA: 1:5000 immunohistochemistry: 1:50-1:100 western blot: 1:500-1:1000 |
| NCBI accession no.【NCBI登记号】 | P24385 |
| UniProt accession no.【UniProt登记号】 | P24385 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... CCND1(595) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | nwg |
