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Anti-CDK4 antibody produced in rabbit

产品编号:3352616
规格:affinity isolated antibody
包装规格:100 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
3352616100 μG4610
产品别名

Anti-CDK4 antibody produced in rabbit

Anti-PSK-J3

Anti-CMM3

基本信息
NACRES
NA.41
General description【一般描述】
The antibody detects endogenous levels of total CDK4 protein.
Immunogen【免疫原】
Peptide sequence around aa. 295-299 (L-H-K-D-E), according to the protein NP_000066.1
Application【应用】
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Features and Benefits【特点和优势】
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form【外形】
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
产品性质
biological source【生物来源】
rabbit
conjugate【偶联物】
unconjugated
antibody form【抗体形式】
affinity isolated antibody
antibody product type
primary antibodies
clone【克隆】
polyclonal
form【形式】
buffered aqueous solution
mol wt【分子量】
~34 kDa
species reactivity
human
concentration【浓度】
1 mg/mL
technique(s)
western blot: 1:500-1:1000
isotype【同位素/亚型】
IgG
immunogen sequence【免疫原序列】
(L-H-K-D-E)
NCBI accession no.【NCBI登记号】
NM_000075.2
UniProt accession no.【UniProt登记号】
P11802
shipped in【运输】
wet ice
storage temp.【储存温度】
−20℃
Gene Information
human ... CDK4(1019)
产品说明
Target description【目标描述】
Cyclin-dependent kinase activity is regulated by T-loop phosphorylation (Thr172 in the case of CDK4), by the abundance of their cyclin partners, and by association with CDK inhibitors of the Cip/Kip or INK family of proteins . The inactive ternary complex of CDK4/cyclin D and p27 Kip1/Cip1 requires extracellular mitogenic stimuli for the release and degradation of p27, which affects progression through the restriction point and pRb-dependent entry into S-phase . The active complex of CDK4/cyclin D targets the retinoblastoma protein for phosphorylation, allowing the release of E2F transcription factors that activate G1/S-phase gene expression . In HeLa cells, upon UV irradiation, upregulation of p16 INK4A association with CDK4/cyclin D3 leads to a G2 delay, implicating CDK4/cyclin D3 activity in progression through the G2-phase of the cell cycle .
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 1
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