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Anti-Cdk1 (p34cdc2) antibody produced in rabbit

产品编号:3352571
规格:whole antiserum
包装规格:0.2 ML
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
33525710.2 ML4330
基本信息
MDL number
MFCD00239719
NACRES
NA.41
General description【一般描述】
The gene Cyclin-dependent kinase 1 (CDK1) is mapped to human chromosome 10q21.1. The protein localizes in the cytoplasm and the nucleus. CDK1 is also popularly called as CDC2.
Immunogen【免疫原】
synthetic peptide corresponding to amino acids 263-287 of the C-terminus of mouse cdk1/cdc2.
Application【应用】
Anti-Cdk1 (p34cdc2) antibody produced in rabbit is suitable for immunoprecipitation and western blot (chemiluminescent) at a dilution of 1:500-1:2,000 using mouse 3T3 cell lysates.
Biochem/physiol Actions【生化/生理作用】
Cyclin-dependent kinase 1 (CDK1) plays a vital role in the control of eukaryotic cell cycle by modulating the centrosome cycle and the onset of mitosis. It promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs. It is essential for development of early embryonic stage. The antibody may cross-react with other cdc2-like kinase. CDK1 is a component of M-phase promoting factor. CDK1 interacts with FAC (Fanconi anemia group C protein) and the binding is important for normal G2/M progression. Similarly, Cep63 binds and recruits Cdk1 to centrosomes, thereby regulating mitotic entry. CDK2 also foms a complex with cyclin E, cyclin A and cyclin D.
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
200
conjugate【偶联物】
unconjugated
antibody form【抗体形式】
whole antiserum
antibody product type
primary antibodies
clone【克隆】
polyclonal
mol wt【分子量】
antigen 34 kDa
contains【包含】
0.05% sodium azide as preservative
species reactivity
human (predicted), rat (predicted), mouse
technique(s)
immunoprecipitation (IP): suitable
western blot (chemiluminescent): 1:500-1:2,000 using mouse 3T3 cell lysates
shipped in【运输】
dry ice
storage temp.【储存温度】
−20℃
Gene Information
human ... CDC2(983)
mouse ... Cdc2a(12534)
rat ... Cdc2(54237)
产品说明
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 3
Personal Protective Equipment【个人防护装备】
Eyeshields, Gloves
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