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Anti-Cdk1 (p34cdc2) antibody produced in rabbit
基本信息
MDL number | MFCD00239719 |
NACRES | NA.41 |
General description【一般描述】 | The gene Cyclin-dependent kinase 1 (CDK1) is mapped to human chromosome 10q21.1. The protein localizes in the cytoplasm and the nucleus. CDK1 is also popularly called as CDC2. |
Immunogen【免疫原】 | synthetic peptide corresponding to amino acids 263-287 of the C-terminus of mouse cdk1/cdc2. |
Application【应用】 | Anti-Cdk1 (p34cdc2) antibody produced in rabbit is suitable for immunoprecipitation and western blot (chemiluminescent) at a dilution of 1:500-1:2,000 using mouse 3T3 cell lysates. |
Biochem/physiol Actions【生化/生理作用】 | Cyclin-dependent kinase 1 (CDK1) plays a vital role in the control of eukaryotic cell cycle by modulating the centrosome cycle and the onset of mitosis. It promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs. It is essential for development of early embryonic stage. The antibody may cross-react with other cdc2-like kinase. CDK1 is a component of M-phase promoting factor. CDK1 interacts with FAC (Fanconi anemia group C protein) and the binding is important for normal G2/M progression. Similarly, Cep63 binds and recruits Cdk1 to centrosomes, thereby regulating mitotic entry. CDK2 also foms a complex with cyclin E, cyclin A and cyclin D. |
产品性质
biological source【生物来源】 | rabbit |
Quality Level【质量水平】 | 200 |
conjugate【偶联物】 | unconjugated |
antibody form【抗体形式】 | whole antiserum |
antibody product type | primary antibodies |
clone【克隆】 | polyclonal |
mol wt【分子量】 | antigen 34 kDa |
contains【包含】 | 0.05% sodium azide as preservative |
species reactivity | human (predicted), rat (predicted), mouse |
technique(s) | immunoprecipitation (IP): suitable western blot (chemiluminescent): 1:500-1:2,000 using mouse 3T3 cell lysates |
shipped in【运输】 | dry ice |
storage temp.【储存温度】 | −20℃ |
Gene Information | human ... CDC2(983) mouse ... Cdc2a(12534) rat ... Cdc2(54237) |
产品说明
Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
WGK | WGK 3 |
Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves |