Anti-BORA antibody produced in rabbit

rabbit

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous solution

human, mouse, rat

immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

Q6PGQ7

Q6PGQ7

dry ice

−20℃

human ... C13orf34(79866)

BORA (aurora borealis) is a conserved protein in vertebrates. BORA is expressed in nucleus and translocated to cytoplasm upon activation by Cyclin-dependent kinase 2 (Cdc2). In human chromosome, the gene BORA is localized on 13q22.1.

Bora antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human Bora.

Anti-BORA antibody produced in rabbit has been used in immunohistochemistry and western blotting studies.

Overexpression of Bora in breast, lung and gastric adenocarcinomas leads to enhanced cell proliferation.

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The action of this antibody can be blocked using blocking peptide SBP3500025.

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Bora (Protein aurora borealis) is a key activator of Aurora Related Protein Kinase A (ARK-1), which is a centrosome-associated serine/threonine kinase that regulates centrosome maturation, bipolar spindle assembly and chromosome segregation during mitosis. Bora is localized to the nucleus until mitosis is initiated, then translocates to the cytoplasm in a Cdc2 dependent manner. Activation of Cdc2 initiates the release of Bora into the cytoplasm where it can bind and activate ARK-1. PLK1 (polo-like kinase-1) interacts with Bora to control the accessibility of its activation loop for phosphorylation and activation by ARK-1. Bora and ARK-1 cooperatively activate PLK1 and control mitotic entry. Bora mutants result in multipolar spindles in mitosis identical to those observed when ARK-1 function is blocked. Thus, the ARK1-Bora-PLK1 regulatory circuit in mammalian cells elucidates a key mechanism in cell cycle regulation. At least three isoforms of Bora are known to exist.

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12 - Non Combustible Liquids

WGK 2