1,1,1-三氯-2-甲基-2-丙醇 半水合物

Cl₃CC(CH₃)₂OH · 0.5H₂O

186.46

878167

249-042-3

MFCD02179352

57647873

meets analytical specification of Ph. Eur., BP, NF

1,1,1-Trichloro-2-methyl-2-propanol hemihydrate (chlorobutanol) is a preservative used as a standard for quantifying preservatives in pharmaceutical formulations by using capillary electrophoretic method. It has also been used to anesthetize leeches for preparing c-DNA library from regenerating retzius cells.

Chlorobutanol or 1,1,1-Trichloro-2-methyl-2-propanol is a opthalmic preservative and sedative hypnotic that possess antibacterial and antifungal properties. It also decreases the conduction velocity and induces conduction failure and automaticity within isolated ventricular muscle strips as well as impacts myocardial cells by acting on cell membrane and reduces isometric tension produced by heart.

200

98-100.5% (calc with ref. to anhyd. subst.)

≤0.002% heavy metals (as Pb)
4.5-5.5% water (Karl Fischer)

≤0.1% (as SO₄)

76-80 ℃

chloride (Cl^-): ≤100 mg/kg

pharmaceutical (small molecule)

O.CC(C)(O)C(Cl)(Cl)Cl.CC(C)(O)C(Cl)(Cl)Cl

1S/2C4H7Cl3O.H2O/c2*1-3(2,8)4(5,6)7;/h2*8H,1-2H3;1H2

WRWLCXJYIMRJIN-UHFFFAOYSA-N

GHS07

Warning

H302

P301 + P312 + P330

Acute Tox. 4 Oral

11 - Combustible Solids

WGK 3

212.0 °F - closed cup

100 ℃ - closed cup

dust mask type N95 (US), Eyeshields, Gloves