Anti-ADAM10 antibody produced in rabbit

MFCD03096586

NA.41

ADAM metallopeptidase domain 10 or A disintegrin and metalloprotease 10 (ADAM10) is a transmembrane protein which is widely distributed. It consists of an amino-terminal signal sequence, a prodomain, a metalloprotease domain, a disintegrin domain, a cysteine-rich region, a transmembrane region and a cytoplasmic tail. The gene encoding this protein is localized on human chromosome 15q21.3.

ADAM10 antibody was raised against a peptide corresponding to amino acids 732 to 748 of human ADAM10. This sequence is identical to those of bovine and rat origins and differs from that of mouse ADAM10 by one amino acid (2,4).

ADAM metallopeptidase domain 10 (ADAM10) activates Notch proteins and has a role in embryonic development. It functions as a molecular scissor and cleaves the extracellular domains of proteins. The protein is a therapeutic target for a variety of diseases and malignancies.

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The action of this antibody can be blocked using blocking peptide SBP3500181.

Supplied in PBS with 0.02% sodium azide.

rabbit

unconjugated

IgG fraction of antiserum

primary antibodies

polyclonal

buffered aqueous solution

predicted mol wt 85 kDa

human

immunocytochemistry: suitable
immunofluorescence: suitable
indirect ELISA: suitable
western blot: suitable

NP_001101

O14672

dry ice

−20℃

human ... ADAM10(102)

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12 - Non Combustible Liquids

WGK 2