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ANTI-ACTIVIN RECEPTOR TYPE IA (ACVR1) (CENTER R147) antibody produced in rabbit
| 产品编号： | 3343126 |
| 规格： | IgG fraction of antiserum, buffered aqueous solution |
| 包装规格： | 400 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
ANTI-ACTIVIN RECEPTOR TYPE IA (ACVR1) (CENTER R147) antibody produced in rabbit
ACVR1
ACVRLK2
Activin receptor type-1
Activin receptor type I
Activin receptor-like kinase 2
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | Activin A receptor type 1 (ACVR1) gene encodes a transmembrane protein that belongs to the bone morphogenetic protein (BMP) type I receptors subfamily of the transforming growth factor-β (TGF-β) receptors. ACVR1 is a single-pass type I membrane protein with a ligand-binding extracellular domain, a transmembrane domain, and a cytoplasmic domain. ACVR1 gene is expressed abundantly in endothelial cells, parenchymal cells, fibroblasts, and tumor-derived epithelial cells. This gene is located on human chromosome 2q24.1. |
| Application【应用】 | Anti-Activin receptor type IA (ACVR1) (CENTER R147) antibody produced in rabbit has been used in immunohistochemistry (1:100) and western blot (1:100). |
| Biochem/physiol Actions【生化/生理作用】 | Activin A receptor type 1 (ACVR1) protein can bind activin in concert with activin receptor type 2 (ActRII) or activin receptor type-2B (ActRIIB). It participates in activin signaling. It is also capable of forming a complex with either the bone morphogenetic protein (BMP)-2/7-bound bone morphogenetic protein receptor type II (BMPR-II) or activin A receptor type 2A/2B (ACVR2A/ACVR2B). Somatic mutations of the ACVR1 gene are associated with primary ovary and colon cancer. It is considered a target gene to fibrodysplasia ossificans progressiva (FOP). |
| Physical form【外形】 | Supplied in PBS with 0.09% (W/V) sodium azide |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | 57153 Da |
| species reactivity | human, mouse |
| technique(s) | immunohistochemistry: 1:50-1:100 western blot: 1:1000 |
| NCBI accession no.【NCBI登记号】 | NP_001096.1 |
| UniProt accession no.【UniProt登记号】 | Q04771 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... ACVR1(90) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
