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Anti-ABCG2 antibody produced in rabbit
产品别名
Anti-ABCG2 antibody produced in rabbit
Anti-CD338
Anti-ABC15
Anti-MRX
Anti-ABCP
Anti-BMDP
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | The ABCG2 (ATP binding cassette subfamily G member 2) gene encodes an ATP-binding cassette (ABC) transporter that is also called as breast cancer resistance protein (BRCP). It is composed of 655 amino-acids and is located on human chromosome 4q22. It belongs to the ABCG (white) subfamily. The antibody detects endogenous level of total ABCG2(CD338) protein. |
| Immunogen【免疫原】 | Peptide sequence around aa. 160-164 ( R-I-N-R-V), according to the protein NP_004818.2 |
| Biochem/physiol Actions【生化/生理作用】 | ABCG2 (ATP binding cassette subfamily G member 2) serves as a shield for several tissues against xenobiotic molecules. It can provide multidrug resistance (MDR) in breast and other cell lines. |
| Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| Physical form【外形】 | Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol |
产品性质
| biological source【生物来源】 | rabbit |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | 65-80 kDa |
| species reactivity | human |
| concentration【浓度】 | 1 mg/mL |
| technique(s) | western blot: 1:500-1:1000 |
| isotype【同位素/亚型】 | IgG |
| immunogen sequence【免疫原序列】 | (R-I-N-R-V) |
| NCBI accession no.【NCBI登记号】 | NM_004827.2 |
| UniProt accession no.【UniProt登记号】 | Q9UNQ0 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... ABCG2(9429) |
产品说明
| Target description【目标描述】 | Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 1 |
