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Anti-α-MSH antibody produced in rabbit

产品编号:3342346
规格:IgG fraction of antiserum, buffered aqueous solution
包装规格:0.2 ML
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
33423460.2 ML4730
产品别名

Anti-α-MSH antibody produced in rabbit

Anti-α-Melanocyte Stimulating Hormone

基本信息
MDL number
MFCD03454727
NACRES
NA.46
General description【一般描述】
Pro-opiomelanocortin (POMC), a complex pro-peptide is expressed in hypothalamus, pituitary gland, skin and the immune system. This gene is located on human chromosome 2p23.3.
Immunogen【免疫原】
synthetic α-MSH peptide conjugated to bovine serum albumin.
Application【应用】
Anti-α-MSH antibody produced in rabbit has been used in:
  • immunohistochemistry
  • radioimmunoassay/α-MSH immunoassay
  • enzyme linked immunosorbent assay (ELISA)

Biochem/physiol Actions【生化/生理作用】
α-MSH (melanocyte stimulating hormone) and melanocortin-4-receptor (MC4R) are key signaling components in the control of energy homeostasis and of the hypothalamic response to obesity. Mutations that reduce the functional activity of -MSH lead to obesity in mammals and mice lacking the MC4 receptor (MC4R-/-) are hyperphagic and very obese, indicating that -MSH signaling transduced by MC4-R limits food intake and body fat mass.
α-Melanocyte Stimulating Hormone (α-MSH) stimulates the production of melanin in melanocytes and induced pigmentation and skin darkening. It increases the activity of tyrosinase that induces melanogenesis. α-MSH has potent anti-inflammatory effects and is also a neuromodulator. Analogs of α-MSH may be used to study melanogenesis and neuromodulation.
Physical form【外形】
0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
200
conjugate【偶联物】
unconjugated
antibody form【抗体形式】
IgG fraction of antiserum
antibody product type
primary antibodies
clone【克隆】
polyclonal
form【形式】
buffered aqueous solution
mol wt【分子量】
antigen 1664.9 kDa
species reactivity
human
technique(s)
ELISA: 1:4,000
microarray: suitable
UniProt accession no.【UniProt登记号】
P01189
shipped in【运输】
dry ice
storage temp.【储存温度】
−20℃
Gene Information
human ... POMC(5443)
产品说明
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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